NeuroScience Calm PRT Decrease norepinephrine to maintain healthy activity while providing ingredients important for regulating the stress response, healthy sleep, and reducing anxiousness Patient Profile: Tired but wired - on edge, yet exhausted Difficulty sleeping at night and waking in the morning Symptoms of overstimulation and adrenaline The Science: In response to stress, the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis signal to the adrenals to release catecholamines (norepinephrine and epinephrine) and cortisol While stress is a normal part of life, it can also be associated with imbalances in the HPA axis that can affect catecholamine and cortisol activity Ingredients Serving Size: 4 Capsules Amount/Serving Proprietary Blend: 1.88 g Rhodiola rosea extract (root)(10% rosavins, providing 112.5 mg of rosavins), Phosphatidylserine 50%, L-glycine, and L-taurine Other Ingredients: Vegetable capsule (hypromellose, water), silica, magnesium stearate (vegetable source), and microcrystalline cellulose. Suggested Use Take 3-4 capsules on an empty stomach one to two times daily or as directed by your healthcare provider. Do not exceed the suggested use. Calm PRT contains ingredients that, when taken at below the suggested use, may cause over-excitation, jitteriness, or agitation. Warning: If you are pregnant or nursing, consult your healthcare provider before use. Keep out of reach of children. Storage: This product has a tamper-evident seal under the cap. Do not use if the seal is broken or missing. Store at room temperature, in a dry place. More Info. HPA axis Increased activity from the HPA axis in response to stressors leads to a “fight or flight” effect. Patients with anxiousness and altered learning show increased HPA axis sensitivity Calm PRT contains ingredients important for reducing cortisol during anxiousness and stress A meta-analysis showed Calm PRT significantly decreased evening cortisol in 106 people (p