Caspase-6 Substrate III Fluorogenic Catalog number: B2014281 Lot number: Batch Dependent Expiration Date: Batch dependent Amount: 2 mg Molecular Weight or Concentration: 819.78 g/mol Supplied as: Powder Applications: molecular tool for various biochemical applications Storage: −20°C Keywords: Caspase-6 Substrate III, Fluorogenic Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um. References Huang S, Mei H, Lu L, Kuang Z, Heng Y, Xu L, Liang X, Qiu M, Pan X. Conformational transitions of caspase-6 in substrate-induced activation process explored by perturbation-response scanning combined with targeted molecular dynamics Comput Struct Biotechnol J. 2021 Jul 24;19:4156-4164. Graham RK, Ehrnhoefer DE, Hayden MR. Caspase-6 and neurodegeneration Trends Neurosci. 2011 Dec;34(12):646-56. Dagbay KB, Bolik-Coulon N, Savinov SN, Hardy JA. Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding J Biol Chem. 2017 Mar 24;292(12):4885-4897. Vaidya S, Velzquez-Delgado EM, Abbruzzese G, Hardy JA. Substrate-induced conformational changes occur in all cleaved forms of caspase-6 J Mol Biol. 2011 Feb 11;406(1):75-91. Wang XJ, Cao Q, Zhang Y, Su XD. Activation and regulation of caspase-6 and its role in neurodegenerative diseases Annu Rev Pharmacol Toxicol. 2015;55:553-72. Velzquez-Delgado EM, Hardy JA. Phosphorylation regulates assembly of the caspase-6 substrate-binding groove Structure. 2012 Apr 4;20(4):742-51. MacPherson DJ, Mills CL, Ondrechen MJ, Hardy JA. Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis J Biol Chem. 2019 Jan 4;294(1):71-88. Bi X, Liu X, Bi D, Sun Y. Identification of Caspase-6 and Caspase-7 from miiuy croaker and evolution analysis in fish Fish Shellfish Immunol. 2018 Dec;83:406-409. Soares J, Lowe MM, Jarstfer MB. The catalytic subunit of human telomerase is a unique caspase-6 and caspase-7 substrate Biochemistry. 2011 Oct 25;50(42):9046-55.
