Specification Full name CD274 rabbit polyclonal antibody Alternative names 50 μl/100 μl Reactivity rabbit polyclonal Applications WB, IHC Host Rabbit Clone type rabbit polyclonal Target Background This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. Swissprot No Q9NZQ7 Gene Accession NP_054862 WB Predicted band size 33 kDa WB Positive control WB Recommended dilution 500-2000 IHC predicted cell location Predicted cell location: Cytoplasm and Cell membrane IHC positive control Positive control: Human esophagus cancer IHC Recommed dilution Recommended dilution: 50-200 Storage -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol WB PIC Description P114203-WB-1-P IHC PIC Description Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue or CD274 antigen-treated (Neutralization experiment) using P114203(CD274 Antibody) at dilution 1/50
