Ortho Molecular CDG EstroDIM Endocrine health CDG EstroDIM includes the combined power of two metabolites to support estrogen balance and breast and prostate health. Estrogen collectively refers to the female hormones estrone, estradiol, and estriol. Estrogen is an important hormone messenger that interacts with cells throughout the body, including tissues that are more sensitive to estrogen, such as the breast and prostate tissues. The most important message they deliver to cells is to grow, divide, and multiply. For this reason, hormones (especially estrogen) are critically important in human development and tissue repair. Supporting proper estrogen synthesis, metabolism, and detoxification is essential for proper hormonal balance. CDG EstroDIM® is a targeted supplement that combines the synergistic benefits of the cruciferous vegetable metabolites indole-3-carbinol (I3C) and 3-3'-diindolylmethane (DIM) to support balanced estrogen metabolism. Formulating I3C and DIM together creates the ideal combination of beneficial metabolites that work together to support estrogen balance and breast and prostate health. Key Benefits and Features: Supports Estrogen Balance Supports Proper Estrogen Metabolism for Women and Men Improves Estrogen Detoxification Pathways and Hormone Excretion Provides Cellular Antioxidant Support for DNA Stability Ingredients Serving Size: 2 Capsules Amount/Serving Vitamin E (from 50 IU as d-Alpha Tocopherol Succinate USP) 33.5 mg Calcium (as Calcium D-Glucarate USP) 120 mg Calcium D-Glucarate USP 1 g Dietary Indoles 300 mg (Total Indole Blend containing Indole-3-Carbinol (I3C, 200 mg input) and Diindolylmethane (DIM, 100 mg input)) Other Ingredients: Hypromellose (natural Vegetable Capsules), Magnesium Stearate, Silicon Dioxide, and Stearic Acid. Does Not Contain: Gluten, corn, yeast, artificial colors or flavors. Suggested Use Take 2 capsules per day or as recommended by your healthcare professional. Warning: Do not consume this product if you are pregnant or nursing. Consult your physician for further information. Keep out of the reach of children. Storage: Keep tightly closed in a cool, dry place. More Info. The Health Benefits of Cruciferous Vegetable Metabolites Many of the health benefits derived from eating cruciferous vegetables (e.g., cabbage, Brussels sprouts, broccoli, etc.), especially those shown to be beneficial for breast and prostate health, are thought to be derived from the group of secondary metabolites known as glucosinolates. When these vegetables are cut, crushed, or chewed, the actions of the enzyme myrosinase (released from the plant cells) hydrolyse these glucosinolates into other compounds. For instance, glucosinolates from broccoli and Brussels sprouts readily convert into I3C when consumed. I3C can then be further converted via stomach acid into other health-promoting compounds, including DIM. These compounds have generally been thought to be responsible for the various cellular activities that lead to hormone health. Preclinical data on I3C and DIM suggest that these phytonutrient metabolites have a strong potential for supporting breast, cervical, endometrium, and prostate health. Together, I3C and DIM promote the metabolism of the more favorable and protective estrogen metabolite, 2-hydroxyestrone (2-OHE), versus production of the less favorable 4-hydroxyestrone (4-OHE) and 16-α-hydroxyesterone (16-αOHE). In contrast to 2-OHE, both 4-OHE and 16-αOHE have been shown to overstimulate cells and create free radicals that contribute to DNA damage. Several human supplementation studies with both male and female subjects consistently show that urinary levels of 2-OHE and the ratio of 2-OHE to 16-αOHE increase following supplementation with I3C. The increases seen in the ratio of 2-OHE to 16-αOHE in subjects supplementing with I3C are advantageous, as this ratio of estrogen metabolites is a marker of a more favorable estrogen metabolite profile.9 With this in mind, CDG EstroDIM® is formulated with targeted doses of both I3C and DIM in two capsules per day to make the daily balancing of hormones easy and convenient. I3C and DIM Indole-3-carbinol (I3C) and 3-3’-diindolylmethane (DIM) are natural metabolites of compounds found in numerous vegetables from the Brassicaceae family. Following I3C ingestion either through the diet or supplementation, I3C molecules combine to form a complex group of compounds in the acidic environment of the stomach, one of which is DIM. In fact, a human pharmacokinetic study evaluated the plasma response to oral supplementation with I3C in 24 healthy women and found that I3C itself was not present in the plasma of subjects, but the only detectable metabolite in plasma samples was DIM.13 The levels of plasma DIM following I3C supplementation increased in a dose-dependent fashion. Both I3C and DIM, as well as many other I3C metabolites, have been shown to impact metabolic shifts and cellular activities for improved health outcomes. I3C and DIM have been shown to induce some phase I and phase II biotransformation genes in preclinical models through pathways such as Nrf2, suggesting I3C and DIM may have a role in detoxification. Additionally, both I3C and DIM have been shown in vitro to decrease aromatase expression, which is the enzyme that converts androgens to estrogen. Further, I3C has been shown to temper estrogen signals by competing for binding sites and inhibiting the activity of estrogen receptors. Calcium D-Glucarate Calcium D-glucarate is the supplemental calcium salt form of D-glucaric acid, a substance produced naturally in the body and obtained through consumption of certain fruits and vegetables. Calcium D-glucarate has been extensively studied and has been shown to inhibit beta-glucuronidase, an enzyme found in certain bacteria that reside in the gut. This activity supports the body’s ability to detoxify estrogens, foreign molecules, and fat-soluble toxins.
