Specification Full name CDK4 rabbit polyclonal antibody Alternative names 50 μl/100 μl Reactivity rabbit polyclonal Applications WB, IHC Host Rabbit Clone type rabbit polyclonal Target Background The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. Swissprot No P11802 Gene Accession BC003644 WB Predicted band size 34 kDa WB Positive control WB Recommended dilution 500-2000 IHC predicted cell location Predicted cell location: Nucleus and Cytoplasm IHC positive control Positive control: Human esophagus cancer IHC Recommed dilution Recommended dilution: 50-300 Storage -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol WB PIC Description P112396-WB-1-P IHC PIC Description Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue or CDK4 antigen-treated (Neutralization experiment) using P112396(CDK4 Antibody) at dilution 1/60
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