CHROMATOCEL® S-060 Silica Gel for Chromatography & Purification
CHROMATOCEL® S-060 from Evonik is a high-purity, powdered amorphous silica gel developed for chromatography, batch extraction, decolorization, and purification applications. Its co ntrolled 230×400 mesh particle distribution, high surface area, neutral pH range, and high silica purity support predictable adsorption and separation performance for small molecules, peptides, lipids, APIs, fine chemicals, and other compatible compounds. Product type: Chromatography-grade powdered silica gel Particle size: 230×400 mesh Surface area: 450–600 m²/g Average pore diameter: Approximately 7 nm (70 Å) Silicon dioxide content: 99.0–100.0 wt.% .sd-summary-box, .sd-support-box, .sd-note-box { margin: 1rem 0 1.25rem; padding: 1rem 1.1rem; border: 1px solid rgba(0,0,0,.10); border-radius: 8px; } .sd-summary-box { background: rgba(66,95,115,.05); } .sd-support-box { border-left: 4px solid var(--sd-accent,#425f73); background: rgba(66,95,115,.06); } .sd-note-box { border-color: rgba(161,98,7,.25); background: rgba(245,158,11,.07); } .sd-summary-box p, .sd-support-box p, .sd-note-box p { margin: .35rem 0; } .sd-specs, .sd-packaging-table, .sd-selection-table { width: 100%; max-width: 840px; border-collapse: separate; border-spacing: 0; } .sd-specs th, .sd-specs td, .sd-packaging-table th, .sd-packaging-table td, .sd-selection-table th, .sd-selection-table td { padding: 10px 12px; border-bottom: 1px solid rgba(0,0,0,.08); text-align: left; vertical-align: top; } .sd-specs th, .sd-packaging-table th, .sd-selection-table th { color: #374151; font-weight: 600; } .sd-specs th { width: 38%; } .checklist li { margin: 6px 0; } .sd-faq { max-width: 840px; margin: 10px 0; padding-bottom: 10px; border-bottom: 1px solid rgba(0,0,0,.08); } .sd-faq summary { cursor: pointer; font-weight: 600; color: var(--sd-ink,#111827); } .sd-faq__a { margin-top: 8px; color: var(--sd-slate,#374151); } .sd-faq__a p { margin: 0 0 8px; } Where it fits Large-scale liquid chromatography: Stationary-phase media for compatible production and process chromatography systems. Small-molecule purification: Separation and cleanup of compatible organic compounds and intermediates. API purification: Process development and production purification of compatible active pharmaceutical ingredients and intermediates. Fine-chemical purification: Removal of impurities and fractionation of specialty chemical streams. Batch extraction: Adsorptive cleanup in compatible liquid-phase extraction processes. Decolorization: Reduction of color bodies and selected polar impurities from compatible process streams. Peptide and lipid separations: Evaluation as an adsorptive medium where silica chemistry and pore structure fit the target separation. Botanical and nutraceutical processing: Purification and fractionation of compatible extracts, subject to process qualification. Why choose CHROMATOCEL S-060? Chromatography-grade silica gel specifically designed for separation and purification work. High surface area: 450–600 m²/g supports efficient adsorptive interaction. Controlled particle distribution: 230×400 mesh for consistent packing and process behavior. Neutral pH range: 6.5–7.5 for compatible compounds and purification systems. Defined pore structure: Approximately 7 nm average pore diameter and 0.60–0.80 mL/g pore volume. High silica purity: 99.0–100.0 wt.% silicon dioxide. Low trace iron and chloride: Each listed at no more than 0.02 wt.%. Suitable for scale-up: Available from smaller industrial quantities through 500 kg bulk bags. Typical properties Product name CHROMATOCEL® S-060 Product type Silica gel / chromatography grade Chemical name Silica gel; silicon dioxide CAS number 112926-00-8 Physical form Powdered amorphous silica gel Particle size 230×400 mesh (approximately 37–63 µm) Surface area 450–600 m²/g Bulk density 500–600 kg/m³ (500–600 g/L) pH 6.5–7.5 Average pore diameter Approximately 7 nm (70 Å); typical range 5–8 nm (50–80 Å) Pore volume 0.60–0.80 mL/g Loss on drying ≤5 wt.% Silicon dioxide content 99.0–100.0 wt.% Chloride content ≤0.02 wt.% Iron content ≤0.02 wt.% Manufacturer Evonik Operations GmbH Evonik identifies these as typical values rather than guaranteed product specifications. Review the current product information and lot-specific documentation when exact qualification limits are required. Particle and pore characteristics Property Process relevance 230×400 mesh particle size Provides a relatively fine adsorbent bed with substantial contact area. Actual flow and pressure behavior depend on column geometry, packing, liquid viscosity, and loading rate. 450–600 m²/g surface area Provides extensive internal adsorptive surface for compatible separation and purification work. Approximately 7 nm pores Supports access by a range of small molecules and compatible larger compounds, depending on molecular dimensions and solvent conditions. 0.60–0.80 mL/g pore volume Provides internal pore capacity for adsorption and chromatographic interaction. pH 6.5–7.5 Offers a near-neutral starting profile for compatible purification processes, although actual slurry and mobile-phase behavior should be confirmed by testing. Application and trial guidance Confirm compatibility using the actual feed material, solvent system, target compounds, and impurity profile. Evaluate adsorption capacity, selectivity, recovery, color reduction, and filtration or column behavior together. For chromatography, establish bed dimensions, packing method, loading rate, eluent composition, flow rate, and fraction criteria through development work. For batch treatment, begin with controlled bench trials and optimize silica dose, mixing, contact time, temperature, and downstream filtration. Monitor pressure rise and flow behavior when using fine silica in packed beds or filtration systems. Use suitable downstream capture equipment to prevent silica fines from remaining in the purified product. Do not assume suitability for a regulated application without completing the required process validation and documentation review. Qualification note: Evonik states that product performance should be verified through testing conducted by qualified personnel. Typical technical values should not be treated as guaranteed process results. Packaging & availability Manufacturer package Published configuration Box 55lb (25kg) Pallet 220lb (100kg) Bulk bag 1,103 lb (500kg) Sorbents Direct quantities: Available order quantities and final package configuration are shown on the product listing or confirmed at quotation. Bulk orders: 500kg bulk bags are available for plant-scale requirements. Lead time: Typically 2-4 weeks, subject to current inventory, quantity, package format, and destination. Freight: Parcel, pallet, or LTL shipping based on quantity and fulfillment configuration. Volume pricing: Automatic quantity discounts may be shown at checkout for qualifying variants. Storage and shelf life Store in the original packaging in a dry, covered location. Keep packaging tightly sealed until use. Reseal partially used containers promptly to minimize atmospheric moisture adsorption. Protect the material from liquid water, humidity, oils, solvents, dust, and foreign contamination. Use clean, dry handling equipment when transferring or repacking the silica. Rotate inventory so older sealed material is used first. Published shelf life: Three years in the original packaging when stored in a dry, covered location. Handling considerations Avoid generating or breathing airborne silica dust. Use suitable local exhaust ventilation during transfer, charging, blending, or cleanup. Wear eye protection and other personal protective equipment required by the current Safety Data Sheet and site risk assessment. Use dry cleanup methods or suitable industrial vacuum equipment rather than dispersing dust with compressed air. Handle spent silica according to the substances it has adsorbed and applicable disposal requirements. Important: Request and review the current Evonik Safety Data Sheet before handling. The Product Information sheet provides technical data but is not a substitute for an SDS. Why buy from Sorbents Direct? Sorbents Direct helps industrial buyers evaluate silica grade, particle size, pore structure, order quantity, documentation, and freight requirements before purchase. Industrial order quantities for trials, pilot work, recurring production, and bulk requirements. Current manufacturer technical data available for qualification and process review. Lot-specific COA support when available for shipped material. Application guidance for chromatography, batch treatment, purification, and decolorization trials. Transparent pricing and volume discounts for qualifying quantities. Freight assistance for parcel, pallet, LTL, and bulk-bag shipments. Documentation & technical support The current Evonik Product Information sheet is available and includes typical properties, composition, applications, packaging, storage guidance, and shelf-life information. The applicable Safety Data Sheet and lot-specific Certificate of Analysis may also be requested. Visit our Documentation Center or contact Sorbents Direct to discuss your feed material, target separation, solvent system, process scale, quantity, and documentation requirements. Questions & answers What is CHROMATOCEL S-060? CHROMATOCEL S-060 is a powdered, chromatography-grade silica gel manufactured by Evonik for chromatography, batch extraction, decolorization, and purification applications. What is its particle size? The published particle distribution is 230×400 mesh, corresponding approximately to 37–63 microns. What is the surface area? The typical surface area is 450–600 m²/g. What is the pore diameter? The published average pore diameter is approximately 7 nm, or 70 angstroms, with a typical range of 5–8 nm. What is the pore volume? The typical pore volume is 0.60–0.80 mL/g. What is the silica purity? Evonik lists silicon dioxide content at 99.0–100.0 wt.%, with chloride and iron each at no more than 0.02 wt.%. What is the loss on drying? The current Product Information sheet lists loss on drying at no more than 5 wt.%. What applications does Evonik specifically list? Evonik lists large-scale liquid chromatography, small-molecule purification, API purification, and fine-chemical purification as typical applications. Can it be used for peptides and lipids? Evonik states that the optimized particle size, surface area, pH, and purity make it useful for separating small molecules, peptides, lipids, and a variety of other compounds. Suitability should be verified using the actual process and target compounds. What package sizes does Evonik publish? Published manufacturer packaging includes 12.7 kg bags, 13.6 kg drums, 27.2 kg drums, and 500 kg bulk bags. Final Sorbents Direct order and fulfillment configurations are confirmed on the listing or at quotation. What is the shelf life? The published shelf life is three years in the original packaging when stored in a dry, covered location. How should it be stored? Keep it sealed in its original packaging in a dry, covered location and minimize exposure to atmospheric moisture. Are the published values guaranteed specifications? No. Evonik labels the data as typical values rather than product specifications. Exact qualification requirements should be reviewed against current documentation and lot-specific data where available. What documentation is available? The Evonik Product Information sheet is available. The applicable Safety Data Sheet and a lot-specific Certificate of Analysis may also be requested. Related products & resources Browse all silica gel and silica adsorbents Explore chromatography and separation media Request product documentation Request technical assistance or a volume quote