Bioactive Collagen Peptide Formula(Bovine) with Vitamin C and Hyaluronic Acid to support healthy joints, mobility and skin. Collagen plus is designed to support healthy joint and mobility in pets that may be ageing, injured or recovering from surgery or injury. Collagen Plus contains high-quality hydrolysed collagen peptides (bovine) designed to stimulate joint cartilage metabolism and counteract joint discomfort. Recent studies have shown when combined with hyaluronic acid and vitamin c that collagen synthesis is optimised in the body, and our blend does just that. Research on collagen has shown beneficial effects on mobility in dogs and cats and contributes to the maintenance of connective tissue, joints, ligaments, bone, and skin. Ingredients 100% pure hydrolysed bioactive collagen peptides (bovine), Liposomal Vitamin C Ascorbic Acid, food grade hyaluronic acid. Dosage Give according to your pet’s weight or as recommended by your animal healthcare professional. Can be given with or without food. Cats can be given 1/4 teaspoon per 2.5kg of body weight Dogs: 0-5kg - 1/2 teaspoon daily 6-15kg - 1 teaspoon daily 15-25kg – 2 teaspoons daily 26-35kg – 3 teaspoons daily 36-45kg - 4 teaspoons daily Over 45kg - 5 teaspoons daily Keep out of reach of children Storage Store below 25 degrees Celsius. Keep in a cool dry place out of direct sunlight. Keep container tightly closed. The Science Balogh L., Polyak A., Mathe D., Kiraly R., Thuróczy J., Terez M., Janoki G., Ting Y., Bucci L.R., Schauss A.G. Absorption, Uptake and Tissue Affinity of High-Molecular-Weight Hyaluronan after Oral Administration in Rats and Dogs. J. Agric. Food Chem. 2008;56:10582–10593. doi: 10.1021/jf8017029. Dobenecker, B., Reese, S., Jahn, W., Schunck, M., Hugenberg, J., Louton, H., & Oesser, S. (2018). Specific bioactive collagen peptides (PETAGILE®) as supplement for horses with osteoarthritis: A two‐centred study. Journal of animal physiology and animal nutrition, 102, 16-23. Minami, S., Hata, M., Tamai, Y., Hashida, M., Takayama, T., Yamamoto, S., ... & Okamoto, Y. (2011). Clinical application of D-glucosamine and scale collagen peptide on canine and feline orthopedic diseases and spondylitis deformans. Carbohydrate polymers, 84(2), 831-834. Serra Aguado CI, Ramos-Plá JJ, Soler C, Segarra S, Moratalla V, Redondo JI. Effects of Oral Hyaluronic Acid Administration in Dogs Following Tibial Tuberosity Advancement Surgery for Cranial Cruciate Ligament Injury. Animals (Basel). 2021 Apr 27;11(5):1264. doi: 10.3390/ani11051264. PMID: 33925642; PMCID: PMC8146498. Schunck, M. , Louton, H. and Oesser, S. (2017) The Effectiveness of Specific Collagen Peptides on Osteoarthritis in Dogs-Impact on Metabolic Processes in Canine Chondrocytes. Open Journal of Animal Sciences, 7, 254-266. doi: 10.4236/ojas.2017.73020. Wang C.-T., Lin J., Chang C.-J., Lin Y.-T., Hou S.-M. Therapeutic Effects of Hyaluronic Acid on Osteoarthritis of the Knee. A meta-analysis of randomized controlled trials. J. Bone Jt. Surg. Am. Vol. 2004;86:538–545. doi: 10.2106/00004623-200403000-00012
