Flexible + Proven: CoolGuard™ Advance provides high-performance protection for temperature-sensitive pharmaceuticals, trusted by life science organizations for secure, single-use cold chain delivery. Designed to perform for up to 120 hours, CoolGuard™ Advance maintains controlled temperatures from −20°C to +25°C using VIP insulation and PCM refrigerants for consistent thermal confidence in transit. Available in sizes from 4L to 96L across multiple temperature ranges, this system features standardized interchangeable components that streamline conditioning, reduce error, and improve pack-out efficiency while lowering freight cost through optimized cubic design. From clinical shipments to commercial biologics, CoolGuard™ Advance keeps your payload — and your supply chain — on track. 12L and 28L shippers in 2–8°C and 15–25°C configurations are now available to order on eCommerce.