DAO Enzyme

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Pure Encapsulations DAO Enzyme Promotes Breakdown of Dietary Histamine Histamine is a substance found in many foods, such as meats, spinach, fermented foods, avocados, nuts, tomato es, and chocolate. An estimated 1-3% of the population cannot digest dietary histamine efficiently, often because of low intestinal diamine oxidase (DAO), an enzyme in the GI tract that normally breaks down histamine. These individuals often experience gastrointestinal discomfort, headache, skin sensitivity, or flushing after consuming histamine-containing foods. Supplementation with DAO enhances DAO activity in the GI tract, promoting breakdown of dietary histamine and reducing gastrointestinal discomfort (occasional diarrhea, bloating, and gas) associated with sensitivity to histamine-rich foods. DAO may also reduce skin symptoms associated with high intestinal histamine levels. In an open-label pilot study, individuals with low DAO levels (< 10 U/ml) who received DAO (10,000 HDU) up to 3 times per day reported significant improvements in gastrointestinal, respiratory, and skin symptom scores after 4 weeks. Subjects reported significant improvement in gastrointestinal comfort, including occasional diarrhea, bloating and gas, headache, respiratory, and skin discomfort. In a double-blind, placebo-controlled, crossover investigation of 22 patients, supplementation of 10,000 HDU DAO twice daily for 30 days improved dietary histamine-associated skin discomfort. Key Benefits and Features: Ages 18 and up Individuals who experience symptoms of histamine intolerance, such as occasional GI upset, skin sensitivity, or flushing Promotes breakdown of dietary histamine Reduces gastrointestinal discomfort (occasional diarrhea, bloating, and gas) associated with sensitivity to histamine-rich foods Eat with greater confidence when histamine may be present in food Acid-resistant capsules protect DAO from degradation in the stomach Ingredients Serving Size: 1 Vegetarian Capsule Amount/Serving Porcine kidney extract (providing 0.55 mU diamine oxidase (DAO) activity) 4.2 mg Other Ingredients: Hypoallergenic plant fiber (cellulose), acid-resistant vegetarian capsule (cellulose, pectin, glycerol, purified water). Does Not Contain: Wheat, soy, dairy, egg, tree nuts, peanuts, gluten, artificial colors, artificial flavors, artificial sweeteners, coating, shellacs, GMOs, unnecessary binders, fillers, preservatives, magnesium stearate, trans fat, and hydrogenated oils. Non-GMO, Gluten-Free Suggested Use As a dietary supplement, take 1 capsule, 2-3 times daily, with each meal, or as directed by a health care professional. Warning: If you are pregnant or lactating, have any health conditions, or are taking any medication, consult your health professional before use. Storage: Store in a cool, dry place. More Info. Diamine oxidase is porcine-derived Show more