Feeling sluggish after histamine-rich meals? Many people experience bloating, skin flare-ups, or headaches after eating foods like cheese, wine, or fermented foods. This is often linked to histamine intolerance, which happens when your body doesn’t have enough of the key digestive enzyme, DAO (Diamine Oxidase). Our DAO Capsules can support the natural breakdown of histamine in the body. Key Benefits Support for the natural metabolism of histamine May support overall digestive well-being Supports the body's natural processes that influence overall vitality A step towards longevity and everyday wellness Product Overview Vegan-friendly, suitable for all diets 23,000 HDU DAO per capsule (a high, effective dose) 60 capsules per bottle Quick and easy to take Backed by third-party testing Diamine Oxidase is the primary enzyme that helps your body process histamine. If your DAO levels are low, histamine can build up and cause various issues after eating certain foods. Naturecan’s DAO Supplement delivers a powerful 23,000 HDU (Histamine Degrading Units) per capsule. HDU is the measure of enzyme activity, the higher the number, the more effective it is at breaking down histamine. With a high-strength, vegan-friendly formula, our DAO capsules can support your body every day. Backed by science, third-party tested, and made in Europe, they’re a trusted choice for anyone who wants more control over their digestion, and histamine metabolism. Dosage Instructions Take one capsule daily, ideally just before a meal ( even better if you know your meal might contain histamine). This way, DAO is right where you need it, when you need it. Stick to the recommended dose and always check with your doctor if you are on medication or have any pre-existing health conditions and feel unsure. Ingredients DAO (Diamine Oxidase), Capsule shell (Hydroxypropyl Methylcellulose), Anti-caking Agent (Magnesium Stearate) Nutritional Information Nutrient Per Capsule DAO (Diamine Oxidase) 23,000 HDU HDU (Histamine Degrading Units) is the unit used to measure enzyme activity. The higher the HDU, the stronger the supplement’s support. Certainty Of Purity At Naturecan, quality is the backbone of everything we do. Our DAO supplement is crafted with pure, natural DAO. Each ingredient is third-party tested to ensure purity, safety, and effectiveness. Science-backed ingredients All-natural and plant-based Made in Europe in GMP-certified facilities Sustainable sourcing and production Full transparency on sourcing and formulation Our commitment to clean, effective supplements guarantees you know exactly what you're putting in your body, with no hidden fillers or nasties. What is Histamine Intolerance? Histamine is a natural compound found in many foods and also produced by the body. It plays important roles in digestion, immune response, and the nervous system. Normally, enzymes like Diamine Oxidase (DAO) help break histamine down in the gut so it doesn’t accumulate. Histamine intolerance happens when your body can’t process histamine effectively, usually because DAO levels are too low. This can lead to an excess build-up after eating histamine-rich foods such as aged cheese, red wine, fermented vegetables, or cured meats. Common symptoms of histamine intolerance include: Bloating, stomach cramps, or digestive discomfort Flushing, itching, or skin irritation Headaches or migraines after certain meals Nasal congestion or allergy-like reactions Unlike food allergies, histamine intolerance isn’t triggered by the immune system, it’s about your body’s reduced ability to clear histamine efficiently. That’s why some people may turn to DAO supplements for extra support in managing histamine levels and easing discomfort. Who should consider taking a Diamine Oxidase supplement? DAO may be a great fit if you: Often react badly to histamine-rich foods Want to reduce bloating or digestive discomfort Care about supporting longevity and overall wellness People who are looking for an easy way to take back control of your diet DAO is not suitable for children, or women who are pregnant or breastfeeding. Ingredients Explained What is DAO and How Does it Work? DAO is one of the body’s natural enzymes, working to keep histamine levels in check. Without enough of it, histamine builds up, which may lead to headaches, skin irritation, or digestive upset. While some foods do contain DAO, it’s difficult to get a high enough concentration through diet alone. Supplementing with DAO gives you a reliable, concentrated amount every day that slots into your day-to-day routine with ease. Led By Experts & Backed By Studies Key Studies DAO and Histamine IntoleranceA recent clinical trial found that DAO supplements helped ease histamine-related symptoms, improving the quality of life for people with histamine intolerance. [1]. DAO and MigrainesAnother study showed that supplementing with DAO reduced the frequency of migraines linked to histamine build-up, highlighting its potential benefits beyond digestion. [2]
