Prescription items are NON-RETURNABLE and NON REFUNDABLE Derma-Vet Ointment (Nystatin Neomycin Sulfate Thiostrepton and Triamcinolone Acetonide Ointment) Nystatin neomycin sulfate thiostrepton and triamcinolone acetonide ointment in a non-irritating vehicle a polyethylene and mineral oil gel base. The preparation is intended for local therapy in a variety of cutaneous disorders of cats and dogs; it is especially useful in disorders caused complicated or threatened by bacterial and/or candidal (monilial) infections. Item Specifications: For Use: Dogs and cats Size: 30ml Manufacturer: Med-Pharmex INDICATIONS: Nystatin neomycin sulfate thiostrepton and triamcinolone acetonide ointment is particularly useful in the treatment of acute and chronic otitis of varied etiologies in interdigital cysts in cats and dogs and in anal gland infections in dogs. The preparation is also indicated in the management of dermatologic disorders characterized by inflammation and dry or exudative dermatitis particularly those caused complicated or threatened by bacterial or candidal (Candida albicans) infections. It is also of value in eczematous dermatitis; contact dermatitis and seborrheic dermatitis; and as an adjunct in the treatment of dermatitis due to parasitic infestation. DOSAGE: Use as Directed by Your Veterinarian DESCRIPTION: Shake well before using. Each mL contains: nystatin 100 000 units neomycin sulfate (equivalent to neomycin base) 2.5 mg. thiostrepton 2 500 units triamcinolone acetonide 1.0 mg. ACTIONS: By virtue of its four active ingredients the ointment provides four basic therapeutic effects: anti-inflammatory antipruritic antifungal and antibacterial. Triamcinolone acetonide is a potent synthetic corticosteroid providing rapid and prolonged symptomatic relief on topical administration. Inflammation edema and pruritus promptly subside and lesions are permitted to heal. Nystatin is the first well tolerated anti-fungal antibiotic of dependable efficacy for the treatment of cutaneous infections caused by Candida albicans (monilia). Nystatin is fungistatic in vitro against a variety of yeast and yeast-like fungi including many fungi pathogenic to animals. No appreciable activity is exhibited against bacteria. Thiostrepton has a high order of activity against gram-positive organisms including many which are resistant to other antibiotics; neomycin exerts antimicrobial action against a wide range of gram-positive and gram-negative bacteria. Together they provide comprehensive therapy against those organisms responsible for most superficial bacterial infections. WARNING: Clinical and experimental data have demonstrated that corticosteroids administered orally or by injection to animals may induce the first stage of parturition if used during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia fetal death retained placenta and metritis. Additionally corticosteroids administered to dogs rabbits and rodents during pregnancy have resulted in cleft palate in the offspring. In dogs other congenital anomalies have resulted; deformed forelegs phocomelia and anasarca. PRECAUTIONS: Nystatin neomycin sulfate thiostrepton and triamcinolone acetonide ointment is not intended for the treatment of deep abscesses or deep-seated infections such as inflammation of the lymphatic vessels. Parenteral antibiotic therapy is indicated in these infections. Nystatin neomycin sulfate thiostrepton and triamcinolone acetonide ointment has been extremely well tolerated. Cutaneous reactions attributable to its use have been extremely rare. The occurrence of systemic reactions is rarely a problem with topical administration. There is some evidence that corticosteroids can be absorbed after topical application and cause systemic effects. Therefore an animal receiving nystatin neomycin sulfate thiostrepton and triamcinolone acetonide ointment therapy should be observed closely for signs such as polydipsia polyuria and increased weight gain. Nystatin neomycin sulfate thiostrepton and triamcinolone acetonide ointment is not generally recommended for the treatment of deep or puncture wounds or serious burns. Sensitivity to neomycin may occur. If redness irritation or swelling persists or increases discontinue use. Do not use if pus is present since the drug may allow the infection to spread. Keep this and all medications out of the reach of children. Avoid ingestion. Oral or parenteral use of corticosteroids (depending on dose duration of use and specific steroid) may result in inhibition of endogenous steroid production following drug withdrawal. SIDE EFFECTS: SAP and SGPT (ALT) enzyme elevations polydypsia/polyuria vomiting and diarrhea (occasionally bloody) have been observed following parenteral or systemic use of synthetic corticosteroids in dogs. Cushing’s syndrome has been reported in association with prolonged or repeated steroid therapy in dogs. Temporary hearing loss has been reported in conjunction with treatment of otitis with products containing corticosteroids. However regression usually occurred following withdrawal of the drug. If hearing dysfunction is noted during the course of treatment with nystatin neomycin sulfate thiostrepton and triamcinolone acetonide ointment discontinue its use. CAUTION: Before instilling any medication into the ear examine the external ear canal thoroughly to be certain the tympanic membrane is not ruptured in order to avoid the possibility of transmitting infection to the middle ear as well as damaging the cochlea or vestibular apparatus from prolonged contact. If hearing or vestibular dysfunction is noted during the course of treatment discontinue the use of nystatin neomycin sulfate thiostrepton and triamcinolone acetonide ointment. STORAGE: 240 mL. bottle. Do not store above 86°F. 7.5 mL 15 mL 30 mL tubes: Store at room temperature; avoid excessive heat (104°F). NADA 140-810 Approved by FDA. Prescription items are NON-RETURNABLE and NON-REFUNDABLE.
