Provides 500 mg Gnosis Saccharomyces cerevisiae (Boulardii) per capsule Supports intestinal beneficial floraRelieves diarrhoeaHelps reduce the occurrence of symptoms of traveller’s diarrhoea when travellingMaintains healthy digestive system functionSupports beneficial gut flora during antibiotic use in adults and childrenShelf-stable, low-excipient, dairy-free formulaVegan friendly DescriptionA probiotic yeastSaccharomyces cerevisiae (Boulardii) (also known as Saccharomyces boulardii or SB) is an unusual probiotic. Most probiotics are beneficial bacteria, but S. boulardii is a yeast. Unrelated to the yeasts which can cause disease, like candida, S. boulardii was identified in the 1920s as an antidiarrhoeal agent after the microbiologist Henri Boulard found that indigenous peoples who consumed a drink prepared from mangosteen and lychee skins did not develop diarrhoea. An important function of the intestinal epithelium is to act as a barrier to prevent bacteria and other microorganisms from crossing into the body tissues. The tight junctions between epithelial cells can widen due to lifestyle, disease or pathogens, compromising the barrier. One way in which S. boulardii protects against infection is by maintaining the structure of tight junctions. When certain pathogenic bacteria enter into the intestinal lumen, the presence of S. boulardii can mitigate the harmful effect. Not only by maintenance of the tight junctions but also by acting directly on the pathogen. An oft-studied pathogen, and the effect of S. boulardii on it, is Clostridium difficile. C. difficile emits two toxins, toxin A and toxin B, which are pro-inflammatory. Animal models propose two mechanisms of action of S. boulardii during C. difficile infection: inhibition of adhesion of toxin A to its receptor, and an immunomodulatory effect whereby S. boulardii increases the circulation of anti-toxin A. Supplementation with S. boulardii has been found to increase levels of Bacteroides and decrease the relative level of Firmicutes. Low levels of Bacteroides have been associated with inflammation of the gut. A high level of Firmicutes is thought to be associated with weight gain.4 It is likely that dysbiosis is a causal factor to these complaints, rather than a side-effect. Gnosis Biootic® S. boulardiiThe S. boulardii in FloraMyces™ is Gnosis Biootic®. Their in-house production from initial fermentation to end product gives a guarantee of quality, with superior stability and a long shelf-life. Gnosis Biootic® is lactose-free, gluten-free, kosher, halal and verified by the Non-GMO Project. Supportive during antibiotic treatment Antibiotic-associated diarrhoea (AAD) is a common side effect of antibiotic therapy. While both bacterial probiotics and S. boulardii can be beneficial for helping to reduce the symptoms and occurrence of AAD, bacterial probiotics are subject to the effect of the antibiotic potentially rendering them less effective. Unlike bacterial probiotics, S. boulardii is not affected by antibiotics. Several systematic reviews and meta-analyses found that S. boulardii reduced the risk of AAD from 17.7-18.7% to 8.0- 8.5% compared with placebo in adults, and from 20.9% to 8.8% in children, or a reduction in relative risk of AAD of 50% or more in children taking S. boulardii. Several studies have shown that taking S. boulardii during and after antibiotic therapy helps to protect the microbiome from negative effects of the antibiotic and helps the microbiome to return to its normal state at an accelerated rate.Supportive while travellingTraveller’s diarrhoea is a common complaint, affecting 20-40 million people a year. Despite increasing awareness of behavioural modifications to prevent traveller’s diarrhoea (for example drinking only bottled water and not taking ice in drinks) there has been a little drop in incidence. Traveller’s diarrhoea is thought to occur from increased exposure to pathogenic bacteria with concurrent dysbiosis due to stress while travelling, medications and dietary changes. A systematic review and meta-analysis of probiotics as a prophylactic against traveller’s diarrhoea found that S. boulardii had the strongest evidence of effectiveness for preventing traveller’s diarrhoea. This is likely due to its ability to maintain a healthy gut microbiome and its immunomodulatory effect in the presence of pathogens. Unlike many bacterial probiotics, S. boulardii does not need to be refrigerated. This makes it a convenient preventative to traveller’s diarrhoea, negating the need for worry over storage Directions for useAdults: Take 1 – 2 capsules per day or as directed by your healthcare professional. Allergen InformationNo added: Gluten, Lactose, Dairy, Seed, Nuts, Egg, Corn, Sesame, Soy.Free From: Artificial Colour, Artificial Flavour, Sulfites.Vegan Friendly WarningsSeek medical advice if diarrhoea persists for more than 6 hours in infants under 6 months, 12 hours in children under 3 years, 24 hours in children aged 3 to 6 years or 48 hours in adultsFloramyces™ provides the well-researched yeast probiotic, Saccharomyces cerevisiae (Boulardii), at a clinically trialled dose shown to relieve diarrhoea and the occurrence of traveller’s diarrhoea. This probiotic assists in maintaining digestive balance and healthy immune function. It supports beneficial bacteria and reduces incidence of diarrhoea during antibiotic use for all ages. With no need for refrigeration, it is suitable for people with lactose intolerance or dairy avoidance. Does not contain – Gluten, dairy, lactose, nuts or seeds. Pack: 30 Capsules
