DIMension 3® represents a three-dimensional approach to supporting healthy estrogen metabolism. Research suggests that diindolylmethane (DIM), curcumin (from turmeric extract), and the patented black pepper extract BioPerine® support balanced estrogen metabolism.* Supports Healthy Estrogen Metabolism in Females and Males* Supports Detoxification of Xenoestrogens* Provides Support for Antioxidant MechanismDIM (3,3’-diindolylmethane) is the stable, bioactive metabolite formed when stomach acid breaks down indole-3-carbinol (I3C), a sulfur-containing glucosinolate present in cruciferous vegetables.[1] Supplementation with DIM is preferred over I3C due to I3C’s undesirable breakdown products, including the dioxin-like molecule indolo[3,2-b]carbazole (ICZ). [2] DIM has been found to support hormone metabolism and immune activity, and stimulate antioxidant and detoxification systems.[3] Curcumin and BioPerine provide ®complementary support for DIM’s role in healthy cell function.* Support of Hormone Metabolism Healthy metabolism of exogenous and endogenous estrogens can be pivotal for hormonal balance.[4] DIM promotes metabolism of estrogen into the favorable and protective 2-hydroxyestrone (2-OHE) metabolite versus production of 4-hydroxyestrone (4-OHE) and 16-alpha-hydroxyestrone (16-alpha- OHE) metabolites.[5] DIM’s influence on 2-OHE production creates a more desirable ratio of 2-OHE to 16-alpha-OHE. Assessment of 2:16-alpha-OHE ratio appears to be useful in evaluating breast health.[6] DIM has been studied for its role in supporting prostate health as well, by reducing dihydrotestosterone binding to androgen receptors.*[7,8]detoxification. Research on DIM suggests that it plays an important role in activating detoxification enzymes in human hepatocytes, further supporting biotransformation at a primary site in the body.*[12] Curcumin As the major curcuminoid found in turmeric, curcumin is valued for its promotion of antioxidant activity, support of metabolic detoxification, and modulation of cytokine production.[13] Research studying genotoxic estrogen metabolites suggests that curcumin’s inhibitory effect on anchorage-independent growth and on CYP enzymes following dioxin exposure helps support healthy cell-life regulation in human embryonic kidney cells and normal prostate cells.*[14]BioPerine is a patented form of piperine, the main alkaloid from black and long pepper plants that has been found to effectively support the absorption of nutrients. After a dose of 2 g of curcumin, human serum levels of curcumin were either undetectable or very low. When the same dose was given along with 20 mg of piperine (4:1 ratio), there was a 2000% increase in the bioavailability of the curcumin without adverse effects.*[15]Support of Cell Function and Metabolism Orchestration of metabolism by the thyroid gland is dependent on hormone balance. DIM was found to target proteolytic enzymes (MMP-2 and MMP-9), thus supporting the normal function and activity of thyroid cells in vitro.[9] Ongoing research reveals DIM’s positive role in regulation of gene expression, protein production, and cell function. Downregulation of certain proteins (survivin, Bcl-2, and cdc25A) and upregulation of protective proteins (NRF2 and cyclin-dependent kinase inhibitor p21waf1) promoted healthy cell growth.*[10,11]Antioxidant and Detoxification Support DIMension 3 provides support for both antioxidant and detoxification systems which, in turn, support cellular function and integrity. Antioxidant activity is crucial to counteracting oxidative molecules normally produced during phase.
