Doctor's Best SAM-e 200 is sourced from Italian Soloesse® SAM-e, delivering gradual and enhanced GI tolerance and absorption. Containing 200 mg of potent Soloesse SAM-e per tablet, Doctor's Best SAM-e aids in restoring SAM-e levels that may be diminished due to age or diet, improving mental well-being. The pure S,S form ensures maximum activity in the body, helping to promote DNA enzymatic actions and neurotransmitter production associated with emotional health. Additionally, SAM-e is clinically proven to enhance joint lubrication and mobility, and assists the liver in forming cholesterol-controlling phosphatidyl-choline and antioxidant L-cysteine. Science-Based Nutrition™ Helps Support Mood and Neural Function Helps Support Joint Comfort and Mobility Helps Support Liver Health and Detoxification Dietary Supplement Vegetarian™ Non-GMO / Gluten Free / Soy Free Formulated with Disulfate Tosylate