Cambridge University Press, 9/3/2007EAN 9780521853767, ISBN10: 0521853761Hardcover, 1894 pages, 28.1 x 22 x 6.5 cmLanguage: EnglishThe endothelium, the cell layer that forms the inner lining of blood vessels, is a spatially distributed system that extends to all areas of the human body. Clinical and basic research demonstrates that the endothelium plays a crucial role in mediating homeostasis and is involved in virtually every disease, either as a primary determinant of pathophysiology or as a victim of collateral damage. The endothelium has remarkable, though largely untapped, diagnostic and therapeutic potential. This volume bridges the bench-to-bedside gap in endothelial biomedicine, advancing research and development and improving human health. The book is the first to systematically integrate knowledge about the endothelium from different organ-specific disciplines, including neurology, pulmonary, cardiology, gastroenterology, rheumatology, infectious disease, hematology-oncology, nephrology, and dermatology. It's interdisciplinary approach, which draws on expertise from such diverse fields as evolutionary biology, comparative biology, molecular and cell biology, mathematical modeling and complexity theory, translational research, and clinical medicine.Part I. ContextPart II. Endothelial Cell as Input-Output DevicePart III. Vascular Bed/Organ Structure and Function in Health and DiseasePart IV. Diagnosis and TreatmentPart V. Challenges and Opportunities."Dr William Aird reveals to us the landscape of this new field in his masterpiece...This comprehensive and authoritative tome is the work of many contributors, but the hand of the editor is seen in every chapter...This is an entertaining, thought-provoking, and exhaustive scholarly work. It must be read by those who aspire to become vascular biologists, and it is a useful reference for those in related fields." --Circulation, the Journal of the American Heart Association "Endothelial Biomedicine is an intellectual tour de force that is a useful reference, comprehensive textbook, and thoroughly engaging work." --Journal of the American Medical Association
