Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) originally isolated from a pineal gland extract called epithalamin. Decades of research led by Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology have studied its role in three foundational longevity pathways: telomere maintenance, melatonin restoration, and biological-rhythm regulation. Unlike daily supplements that target one symptom of aging at a time, Epithalon works upstream at the cellular-signaling level — supporting telomerase activity, restoring age-related decline in pineal melatonin output, and reinforcing the body’s antioxidant defenses. It is administered as a small subcutaneous injection in short cycles (typically 10–20 days, run 1–2 times per year), not daily indefinitely. What patients report during a cycle: Deeper, more continuous sleep within the first week Improved energy and recovery in the second half of the cycle Subjective improvements in skin tone, vitality, and overall well-being that persist for weeks to months after the cycle ends Available strengths: 10 mg/mL × 5 mL vial (50 mg total) — standard cycle strength 2 mg/mL × 5 mL vial (10 mg total) — lower-dose option for sensitive users or starter cycles Every Epithalon prescription is reviewed by a licensed physician and dispensed through an FDA-registered, NABP- and LegitScript-accredited compounding pharmacy. Refrigerate at 2–8°C. Use within 30 days of reconstitution. Epithalon is not FDA-approved as a finished pharmaceutical product. It is prescribed off-label following a clinical evaluation. Not appropriate for those who are pregnant, breastfeeding, or have an active malignancy.
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