*PLEASE NOTE* 50mg Epitalon will take a lot of BAC water to reconstitute, especially if you refrigerate it. We highly recommend doing the reconstitution at room temp with 3ML of BAC water then transferring it into a larger vial and adding an additional 1ML of BAC water so it dissolves fully and doesn't fall out of suspension when refrigerated. Epithalon/Epitalon Description Epithalon (also known as Epitalon) is a synthetic tetrapeptide derivative of Epithalamin composed of four amino acids (Ala-Glu-Asp-Gly). Primarily studied for its potential anti-aging properties, research suggests it may influence telomere length and activate telomerase, the enzyme that rebuilds telomeres (the protective caps at the end of chromosomes). Peptide Information Property Value Peptide Sequence Ala-Glu-Asp-Gly Molecular Formula C14H22N4O9 Molecular Weight 390.35 g/mol CAS Number 307297-39-8 PubChem CID 219042 Synonyms 307297-39-8, Glycine, L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-, Ala-Glu-Asp-Gly Scientific Overview of Epithalon Epithalon, also referred to as Epitalon, is a synthetic peptide that has been studied for its possible involvement in cellular aging processes. Experimental investigations suggest that it may interact with telomerase activity and influence melatonin production. Research has also explored its potential relevance to areas such as oxidative stress, gene regulation, and circadian rhythm. Alternative Names: Epitalon, Epithalone, Epithalamin Studies and Research Data Investigations into DNA Regulation and Gene Expression Laboratory studies suggest that Epithalon may influence the regulation of certain genes. Findings indicate possible interactions with promoter regions of genes linked to immune system function, extracellular matrix maintenance, and cellular signaling. Experimental data also propose that Epithalon may modulate histone-DNA interactions, potentially altering chromatin accessibility and influencing transcription processes. Research in stem cells has suggested an upregulation of markers associated with neuronal differentiation, which could point toward possible roles in epigenetic regulation. Epithalon Exploration of Melatonin Secretion Research on rodent and primate models has examined whether Epithalon may play a role in melatonin synthesis. The peptide has been studied for its potential influence on enzymes and proteins associated with circadian rhythm, suggesting a possible connection to the regulation of sleep-related hormonal cycles. Research Related to Oocyte and Cellular Aging Studies on oocyte models have proposed that Epithalon may help preserve cellular structure during the aging process. Evidence includes observations of reduced oxidative stress markers, improved mitochondrial parameters, and decreased indicators of DNA damage. These findings suggest potential roles for the peptide in supporting cellular stability under conditions of stress. Epithalon Studies on Tumor Growth Pathways Rodent experiments have investigated Epithalon in the context of cancer research, with particular attention to its potential modulation of circadian-related genes. For example, PER1 gene activity, which is often reduced in tumor progression, has been examined as a possible pathway of interest. Preliminary data suggest that Epithalon may influence tumor development and radiation sensitivity, though further research is needed. Research into Extracellular Matrix Dynamics Epithalon has been explored for its possible impact on extracellular matrix (ECM) proteins, such as MMP2, which are associated with tissue remodeling. In animal studies, peptide exposure was linked with increased fibroblast activity, suggesting potential roles in connective tissue processes. Investigations have also considered whether Epithalon may interact with enzymes involved in programmed cell death, raising questions about its relevance to cell survival. Epithalon Investigations into Visual Function Rat models of retinal degeneration have been used to evaluate Epithalon’s potential impact on eye structure and retinal bioelectrical activity. Some studies suggest improvements in structural preservation and functional outcomes, though the mechanisms remain under investigation. Conclusion Research on Epithalon spans diverse themes, including cellular aging, gene expression, circadian regulation, extracellular matrix dynamics, and visual function. Findings are preliminary, and while they suggest multiple possible biological pathways of interest, further studies are required to clarify mechanisms and implications. For Research Use OnlyThis compound is provided exclusively for in vitro laboratory research. It is not intended for human or animal consumption, diagnosis, treatment, or medical use. Not for dietary, cosmetic, or veterinary purposes. This product has not been evaluated by the U.S. Food and Drug Administration or any other regulatory authority. DisclaimerAll information is for educational purposes only. Humatide makes no claims regarding efficacy or safety. Purchasers are responsible for ensuring proper handling and use in compliance with all applicable laws and regulations. Terms of SaleBy purchasing from Humatide, you confirm that you are a qualified researcher with the knowledge and facilities to safely handle and store research chemicals. All sales are final. Humatide assumes no liability for misuse, misrepresentation, or unintended consequences arising from the use of this product.
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