Pancreatic Enzyme Replacement Powder for Dogs and Cats with EPI Product Description Epizyme Powder is a prescription-based pancreatic enzyme concentrate of porcine origin, specially formulated to support dogs and cats with exocrine pancreatic insufficiency (EPI). It supplies the full range of enzymes needed for digestion, including lipase, protease, amylase, esterases, peptidases, elastase, and nucleases, so fats, proteins, and carbohydrates are properly broken down and absorbed Benefits Restores Enzyme Function: Replaces the pancreatic enzymes that pets with EPI cannot produce, allowing normal digestion of essential nutrients to resume. Improves Nutrient Absorption: Helps dogs and cats properly digest and absorb proteins, carbohydrates, and fats that would otherwise pass undigested. Supports Weight Management: Aids in returning pets to a healthy body weight, as unexplained weight loss is a common and serious symptom of EPI. Triple-Enzyme Formula: Contains lipase, protease, and amylase, each targeting fats, proteins, and carbohydrates respectively, for comprehensive digestive support. Whole & Activated Pancreatic Concentrate: Made from whole, raw, and activated porcine pancreas with standardized enzyme activities for reliable and consistent results. FDA-Approved for Pets: Epizyme is FDA-approved for use in cats and dogs specifically to treat exocrine pancreatic insufficiency. Easy to Administer: The powder form mixes easily into wet or moistened dry food, making it simple to give with every meal. Ingredients Active Ingredients Lipase, Protease, Amylase Other Ingredients Esterases, Peptidases, Elastase, Nucleases Per Teaspoon (2.8g): Fat 260g, Protein 388g, Starch 460g How to Use Dosage & Administration Instructions Prescription Required: Epizyme is an Rx-only medication and must be given exactly as directed by your veterinarian before starting any dosing routine. Dosage for Dogs: Adult dogs should receive 3/4 to 1 teaspoonful (2.8g teaspoon) of Epizyme Powder mixed into food with each meal. Dosage for Cats: Adult cats should receive 1/4 to 3/4 teaspoonful (2.8g teaspoon) of Epizyme Powder mixed into their food with each meal. Mix Thoroughly with Food: Add the powder to moistened dry or canned food and mix very thoroughly so enzymes come into close contact with all food particles. Allow to Sit Before Feeding: Let the food and powder mixture rest for at least 5 minutes before serving, as a 15 to 20 minute room-temperature incubation further enhances the digestive process. Feed Small, Frequent Meals: Pets on Epizyme should be fed a minimum of 3 small meals per day rather than one or two large meals for better enzyme effectiveness. Long-Term Use: In most cases, Epizyme is a lifelong treatment, as EPI is a chronic condition where the pancreas cannot recover normal enzyme production. Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet. Additional Information Precautions Veterinary Prescription Only: This is an Rx medication and should only be used under veterinary supervision; do not administer without a valid prescription. Not for Pets with Known Hypersensitivity: Do not use Epizyme in pets with a known allergy or hypersensitivity to any of its ingredients, including porcine-derived components. For Pets Only: Epizyme is prescribed exclusively for dogs and cats. It is not suitable for human use under any circumstance. Restrict Access Always: Keep this product well out of reach of children and other animals to eliminate any chance of accidental ingestion. Possible Side Effects Gradual Full Recovery: Digestion often responds early, but weight, stool consistency, and coat condition can take longer to return fully to normal. Seek Vet Reassessment: No visible improvement in digestion or ongoing weight loss after starting Epizyme means a vet review of the dosage is needed. Storage Information Room Temperature Storage: Store Epizyme Powder at room temperature, protected from excess heat, light, and moisture to preserve enzyme activity. Use a Tight, Light-Resistant Container: Keep the powder in its original childproof, light-resistant container with the lid tightly closed after every use. Keep Away from Children and Pets: Store in a location that is completely out of reach of both children and other animals to prevent accidental exposure. Shipping & Return We offer ground, express, and priority delivery; see our shipping policy for details. For return instructions or product concerns, please refer to our detailed refund policy. Prescription items are NON-RETURNABLE and NON-REFUNDABLE. Frequently Asked Questions Q1: What is Epizyme Powder used for in dogs and cats? Ans: Epizyme Powder is used to treat exocrine pancreatic insufficiency (EPI) in dogs and cats. It replaces the digestive enzymes the pancreas fails to produce, helping pets properly break down and absorb proteins, fats, and carbohydrates from their meals. Q2: How long does Epizyme take to show results in pets? Ans: Digestion typically begins to improve with the very first dose. However, it may take additional time before your pet's weight, stool consistency, and coat condition fully return to normal. Results vary depending on each pet's condition. Q3: How do I give Epizyme Powder to my dog or cat? Ans: Mix the powder thoroughly into moistened dry or canned food and allow the mixture to sit at room temperature for at least 5 minutes before serving. A 15 to 20-minute rest period can further improve the digestive process and enzyme effectiveness. Q4: How long does my pet need to take Epizyme pancreatic enzyme powder? Ans: In most cases, Epizyme is a lifelong treatment. EPI is a chronic condition where the pancreas is unable to recover normal enzyme production, so ongoing daily administration is typically required to maintain healthy digestion. Q5: Does Epizyme Powder require a prescription from a veterinarian? Ans: Yes, Epizyme is an Rx-only, FDA-approved medication. It must be prescribed by a licensed veterinarian and should only be used under ongoing veterinary supervision to ensure the correct dosage and monitoring for your pet. Q6: What are the active enzymes in Epizyme Powder for pets? Ans: Epizyme contains a porcine-origin pancreatic enzyme concentrate standardized for lipase, protease, and amylase activity. It also includes esterases, peptidases, elastase, and nucleases for broad-spectrum digestive support. Q7: How many times a day should I feed my pet while using Epizyme EPI treatment? Ans: Pets on Epizyme should be fed a minimum of 3 small meals per day. Frequent, smaller feedings help the enzymes work more effectively with each portion of food, supporting better nutrient digestion and absorption throughout the day. Clinical Research https://www.drugs.com/vet/v-e-t-pharmaceuticals-epizyme.html https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.922130/full
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