Estrus Control and Reproductive Support for Cattle Product Description Estrumate® is a sterile cloprostenol injection designed to support reproductive management in beef cows, lactating dairy cows, and replacement heifers. As a synthetic prostaglandin F2 alpha analogue, it induces luteolysis to help regulate estrus, treat specific reproductive conditions, support synchronization programs, and assist in controlled breeding protocols under veterinary supervision. Benefits Induces Luteolysis: Promotes functional and structural regression of the corpus luteum to initiate estrus within 2 to 5 days. Supports Estrus Detection: Helps manage unobserved or non-detected estrus in cycling cows and heifers. Treats Uterine Conditions: Assists in resolving pyometra and chronic endometritis by restoring normal cyclic activity. Manages Luteal Cysts: Encourages regression of luteal cysts to restore normal ovarian function. Enables Synchronization: Supports single or double injection protocols for controlled estrus synchronization programs. FTAI Protocol Use: Works with Fertagyl® in structured programs to enable fixed-time artificial insemination in dairy cows. No Withdrawal Period: No milk discard or pre-slaughter withdrawal required when used as labeled. Variants Estrumate (cloprostenol) Injection is available in the following sizes: 20 mL multidose vial 100 mL multidose vial Ingredients Composition Table Ingredient Quantity Cloprostenol 250 mcg per mL Cloprostenol sodium equivalent 263 mcg per mL Sodium citrate 6.1 mg per mL Anhydrous citric acid 0.56 mg per mL Sodium chloride 6.7 mg per mL Benzyl alcohol 20 mg per mL Other Ingredients: Water for injection, q.s. How to Use Recommended-Dosage Chart Indication Recommended Dose Route Timing Notes Unobserved or non-detected estrus 2 mL per animal Intramuscular injection Estrus expected within 2 to 5 days post-injection Pyometra or chronic endometritis 2 mL per animal Intramuscular injection Return to cyclicity typically within 14 days Mummified fetus 2 mL per animal Intramuscular injection Expulsion usually follows luteolysis Luteal cysts 2 mL per animal Intramuscular injection Restores normal ovarian activity Abortion up to 5 months of gestation 2 mL per animal Intramuscular injection Fetus expelled about 4 to 5 days post-injection Estrus synchronization single injection 2 mL per animal Intramuscular injection Breed at estrus or at 72 and 96 hours Estrus synchronization double injection 2 mL per animal each injection Intramuscular injection Second dose 11 days after first injection FTAI with Fertagyl® 2 mL per animal Intramuscular injection Administer 6 to 8 days after first Fertagyl dose Dosage & Administration Instructions Standard Dose: Administer 2 mL containing 500 mcg cloprostenol by intramuscular injection per animal. Intramuscular Route: Use only the intramuscular injection technique to ensure proper absorption and effectiveness. Mature Corpus Luteum: Ensure ovulation occurred at least 5 days prior for optimal luteolytic response. Double Injection Timing: Administer the second injection 11 days after the first in double synchronization programs. FTAI Protocol: Follow the structured Fertagyl and Estrumate timing schedule for fixed-time artificial insemination programs. Prescription Only: Federal law restricts use to licensed veterinarians or on their order. Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet. Additional Information Precautions Avoid Pregnancy: Do not administer to pregnant cattle unless abortion is intentionally desired. Human Safety Risk: Avoid skin contact as absorption may cause abortion or bronchospasms in humans. Respiratory Caution: Women of childbearing age and asthmatics should exercise extreme handling caution. Aseptic Technique: Employ careful aseptic injection practices to reduce post-injection bacterial infections. Injection Site Monitoring: Monitor for clostridial infections and initiate aggressive antibiotic therapy at the first signs. Possible Side Effects Injection Infections: Severe localized clostridial infections have been reported in rare cases. Increased Uneasiness: Mild uneasiness may occur at 50 to 100 times the recommended dosage. Slight Frothing: Slight frothing has been observed at significantly elevated doses. Milk Let Down: Milk let down may occur at extremely high doses. Storage Information Protect From Light: Keep the product protected from light to maintain stability. Store In Carton: Retain product in original carton during storage. Temperature Range: Store between 2 and 30 degrees Celsius or 36 to 86 degrees Fahrenheit. Use Within 28 Days: Discard vial 28 days after first puncture. Puncture Limits: For a 100 mL vial, do not exceed 12 punctures. Shipping & Return We offer ground, express, priority, and international delivery; see our shipping policy for details. For return instructions or product concerns, please refer to our detailed refund policy. Prescription items are NON-RETURNABLE and NON-REFUNDABLE. Frequently Asked Questions Q1: What is Estrumate® used for in cattle? Ans: Estrumate® is indicated for unobserved estrus, pyometra, chronic endometritis, mummified fetus, luteal cysts, abortion up to about five months of gestation, estrus synchronization, and use with Fertagyl® for fixed time artificial insemination in lactating dairy cows under veterinary supervision. Q2: How does Estrumate® work in cows and heifers? Ans: Estrumate® contains cloprostenol, a synthetic prostaglandin F2 alpha analogue that induces luteolysis by causing regression of the corpus luteum. In cycling non-pregnant cattle, this action typically results in estrus within 2 to 5 days after treatment. Q3: What is the recommended dose of Estrumate®? Ans: The recommended dose is 2 mL per animal, which provides 500 mcg of cloprostenol, given by intramuscular injection. The timing of treatment will vary based on the specific use and the breeding program in place, including whether a single or double injection synchronization protocol is being followed. Q4: Is there a milk or meat withdrawal period for Estrumate®? Ans: When used according to label directions, Estrumate® does not require a milk discard period or a pre-slaughter drug withdrawal period. Use in excess of the approved dose may result in drug residues. Q5: Can Estrumate® be used in pregnant cattle? Ans: Estrumate® should not be used in pregnant cattle unless abortion is desired. Its luteolytic action may induce abortion depending on the stage of gestation, with effectiveness decreasing beyond the fifth month. Clinical Research https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=634a706f-4a00-4a04-86ae-a4d8c22b8271
