ETAR (D424) Polyclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: BS3165-50, BS3165-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: Endothelin receptor A (ETAR), also known as EDNRA, ET1 receptor, ETA, EDN1 and ET-AR, is a member of the guanine-binding regμlatory protein-coupled receptor family. ETAR binds endothelins and has the highest affinity for its ligand, ET1, as compared to the ETBR receptor. Both ET receptors, ETAR and ETBR, are activated by ET1, which resμlts in inhibition of active lens sodiumpotassium transport. Activation of the ET receptors also causes an increase in cytoplasmic calcium concentration in cμltured lens epithelial cells. In addition, ETAR induces arachidonic acid accumμlation. ETAR has seven hydrophobic transmembrane domains and is expressed in aorta, lung, atrium, kidney, placenta and prostate. Specifically, placental vascμlar smooth muscle cells (PVSMCs) exclusively express ETAR. Category: Primary Antibody Reactivity: Human, Mouse, Rat Host: Rabbit Applications: IHC, IF Alternate Names: Endothelin-1 receptor, Endothelin A receptor, ET-A, ETA-R, hET-AR, EDNRA, ETA, ETRA Clonality: Polyclonal Conjugate: Unconjugated Modification: Unmodification Immunogen: Synthetic peptide, corresponding to amino acids 400-450 of Human ETAR. Dilution: IHC: 1:50~1:200 IF: 1:50~1:200 Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). Specificity: ETAR (D424) polyclonal antibody detects endogenous levels of ETAR protein. Molecular Weight: ~ 46 kDa Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. SwissProt: P25101 Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Research Use Only
