Factor Xa Chromogenic Substrate Catalog number: B2012709 Lot number: Batch Dependent Expiration Date: Batch dependent Amount: 5 mg Molecular Weight or Concentration: N/A Supplied as: Lyophilized Powder Applications: molecular tool for various biochemical applications Storage: 2-8°C Keywords: CH3OCO-D-CHA-Gly-Arg-pNA-AcOH Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um. References Yuri M, Tabe Y, Tsuchiya K, Sadatsuki R, Aoki J, Horii T, Iba T, Ohsaka A. Evaluation of Factor Xa-Specific Chromogenic Substrate Assays and the Determination of Pharmacokinetics of Fondaparinux Clin Appl Thromb Hemost. 2016 Jul;22(5):453-8. Rosen S, Tiefenbacher S, Robinson M, Huang M, Srimani J, Mackenzie D, Christianson T, Pasi KJ, Rangarajan S, Symington E, Giermasz A, Pierce GF, Kim B, Zoog SJ, Vettermann C. Activity of transgene-produced B-domain-deleted factor VIII in human plasma following AAV5 gene therapy Blood. 2020 Nov 26;136(22):2524-2534. Drozd NN, Kuznetsova SA, Malyar YN, Kazachenko AS, Borovkova VS, Berezhnaya YD. Thrombin and Factor Xa Hydrolysis of Chromogenic Substrates in the Presence of Sulfated Derivatives of Galactomannan and Galactoglucomannan Natural Gels Pharmaceutics. 2022 Dec 1;14(12):2678. Lollar P, Knutson GJ, Fass DN. Activation of porcine factor VIII:C by thrombin and factor Xa Biochemistry. 1985 Dec 31;24(27):8056-64. Harenberg J, Krämer R, Giese C, Marx S, Weiss C, Wehling M. Determination of rivaroxaban by different factor Xa specific chromogenic substrate assays: reduction of interassay variability J Thromb Thrombolysis. 2011 Oct;32(3):267-71. Bohling SD, Pagano MB, Stitzel MR, Ferrell C, Yeung W, Chandler WL. comparison of clot-based vs chromogenic factor Xa procoagulant phospholipid activity assays Am J Clin Pathol. 2012 Feb;137(2):185-92. Madaras F, Chew MY, Parkin JD. Automated estimation of factor Xa using the chromogenic substrate S-2222 Haemostasis. 1981;10(5):271-5. Nishibe H. The assay of factor V in plasma using a synthetic chromogenic substrate Clin Chim Acta. 1980 Oct 9;106(3):301-7. Bardy G, Fischer F, Appert A, Baldin B, Stève M, Spreux A, Lavrut T, Drici MD. Is anti-factor Xa chromogenic assay for Rivaroxaban appropriate in clinical practice? Advantages and comparative drawbacks Thromb Res. 2015 Aug;136(2):396-401.
