OverviewFirst Defense Scour Bolus by ImmuCell is an oral bolus containing concentrated antibodies against the two most common infectious causes of neonatal calf scours — Escherichia coli K99 (enterotoxigenic E. coli) and bovine coronavirus. Administered orally to newborn calves within the first 12 hours of life, First Defense delivers targeted passive immunity directly to the GI tract, where it works locally to neutralize E. coli K99 and coronavirus before they can colonize and cause disease. Unlike colostrum, which provides systemic passive immunity, First Defense provides targeted local GI protection — making it a valuable complement to colostrum management in high-risk calving environments. Calf scours is the leading cause of death in beef and dairy calves, and E. coli K99 and coronavirus are two of the most significant infectious contributors. First Defense is the only USDA-licensed product of its kind proven to reduce the incidence of scours caused by these two pathogens. Sold in a 5-dose pack. Requires refrigeration.Key Features Oral bolus delivering concentrated antibodies against E. coli K99 and bovine coronavirus Provides targeted local GI passive immunity — neutralizes pathogens before they colonize the gut Administer within the first 12 hours of life for maximum effectiveness USDA-licensed — the only product of its kind proven to reduce scours from E. coli K99 and coronavirus Complements colostrum management in high-risk calving environments Easy oral bolus administration — no injection required 5-dose pack for calving season use Requires refrigeration — store between 35–45°F (2–7°C) Specifications Brand: ImmuCell / First Defense Product: First Defense Scour Bolus Coverage: E. coli K99, Bovine Coronavirus Administration: Oral bolus — within first 12 hours of life Pack Size: 5 doses Storage: Refrigerate 35–45°F (2–7°C) — do not freeze Species: Beef and dairy calves Best For Newborn calf scours prevention in beef cow-calf and dairy operations High-risk calving environments where scours pressure from E. coli K99 and coronavirus is a concern Operations where colostrum quality or quantity is uncertain and additional GI protection is needed Producers looking for a USDA-licensed, proven scours prevention tool for newborn calves Administer within the first 12 hours of life per label directions. Refrigerate — do not freeze. Consult your veterinarian for guidance on neonatal calf health programs and scours prevention protocols.
