Please send an e-mail to [email protected] if you would like to receive a quote, place a bulk order or if you wish to place your order manually. CAS Number: 60842-46-8 Fluorescein isothiocyanate (FITC)-dextrans are synthesised by coupling fluoresceinyl isothiocyanate (5-isomer) to selected dextran fractions. All the batches are checked for molecular weight, degree of substitution, loss on drying and free FITC. TdB Labs produces FITC-dextrans from 4 kDa to 2000 kDa that are supplied as a yellow to orange powder. StructureDextran is a branched polysaccharide elaborated by the bacteria Leuconostoc mesenteroides B512F. Dextran is essentially a linear glucose chain linked by α-D-(1 – 6) linkages. The degree of branching is about 5 %. The fluorescein moiety is attached by a stable thiocarbamoyl linkage and the labelling procedure does not lead to any depolymerization of the dextran. FITC-dextrans have from 0.001-0.020 mol FITC per glucose unit. These low levels of substitution confer minimal charges to dextran, which is an essential requirement for permeability studies. Spectral dataFITC-dextran has an excitation maximum of 490 – 495 nm and an emission maximum of 520 ± 5 nm. Maximal intensity is observed at pH >8. Storage and stabilityFITC-dextran is stable for more than 6 years when stored dry in well-sealed containers at ambient temperature. SolubilityFITC-dextran dissolves readily in water. ApplicationFITC-dextran is mainly used for studying permeability and microcirculation. It can also be used as a molecular size marker, for studies of drug delivery and more. FITC-dextrans are also very sensitive to the pH of their environment and they can be utilized as pH-indicators. If you need larger quantities please contact us for a bulk quotation. Technical information Download SDS Download datafile Specifications FITC-dextran 4 FITC-dextran 10 FITC-dextran 20 FITC-dextran 40 FITC-dextran 70 FITC-dextran 110 FITC-dextran 150 FITC-dextran 500 FITC-dextran 2000
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