Injectable NSAID for Pain, Inflammation, and Fever in Horses and Cattle Product Description Flunixin Meglumine Injection 50mg/mL is a prescription nonsteroidal anti-inflammatory drug used by veterinarians to treat pain, inflammation, and fever in horses and cattle. It works by blocking prostaglandin production, which dials down the body's pain and inflammatory response at a cellular level. In horses, it covers musculoskeletal disorders and visceral pain from colic, and in cattle, it addresses fever and inflammation tied to respiratory disease, mastitis, and endotoxemia. It is given intravenously under direct veterinary supervision. Benefits Equine Colic Pain Relief: Delivers strong visceral pain relief during colic episodes in horses, helping keep the animal stable while the cause is being worked out. Cattle Fever and Inflammation: Carries FDA approval for bringing fever and inflammation from respiratory disease, mastitis, and endotoxemia under control in cattle. Rapid Intravenous Action: Given into the vein, this formulation acts faster than the paste version, making it well-suited for acute and urgent situations. Endotoxic Shock Support: Part of a veterinarian-directed plan for managing endotoxic shock and circulatory compromise in horses and cattle. Musculoskeletal Inflammation: Eases pain and inflammation from soft tissue injuries, lameness, and musculoskeletal disorders in horses under veterinary care. Ingredients Active Ingredients Flunixin Meglumine 50mg/mL How to Use Flunixin Meglumine Injection 50mg/mL is a prescription-only medication. A valid veterinarian's prescription is required to purchase this product. Please follow your veterinarian's specific instructions for the dosage and administration of this medication for your animal. Disclaimer: Dosage and administration of this medication must be determined by a licensed veterinarian. Always consult your veterinarian before administering or adjusting any prescription medication for your animal. Additional Information Precautions Intravenous Use Only in Horses: Intramuscular use in horses is not safe, as an accidental intra-arterial injection can trigger serious neurological reactions. IM Use Risk in Cattle: In cattle, giving this medication intramuscularly has led to violative tissue residues at slaughter and should only be used as a veterinarian directs. Do Not Exceed 5 Days: Going past five consecutive days of treatment raises the risk of serious gastrointestinal, kidney, and liver complications in animals. Avoid in Dehydrated Animals: Animals that are dehydrated, hypovolemic, or hypotensive should not receive this medication, as the risk of kidney damage climbs sharply in those conditions. Avoid Combining With NSAIDs or Corticosteroids: Using other anti-inflammatory drugs alongside this medication puts animals at a much higher risk of gastrointestinal ulceration and organ toxicity. Caution in Organ Disease: Animals with existing liver, kidney, or cardiovascular conditions face a notably higher chance of serious adverse effects from this medication. Not for Human Consumption Animals: This medication must not be used in horses or cattle that are intended for human consumption. Possible Side Effects Gastrointestinal Ulceration: Giving too much or using it for too long can lead to gastrointestinal ulcers and right dorsal colitis in horses on this medication. Kidney Toxicity: The kidneys can be affected, especially in dehydrated animals or those already receiving diuretics while on this medication. Intra-Arterial Reaction in Horses: If the injection accidentally enters an artery in horses, it can bring on ataxia, incoordination, rapid breathing, and agitation that usually clears without treatment. Injection Site Reactions: Intramuscular use can leave behind localized pain, swelling, muscle inflammation, and tissue damage at the site of injection. Allergic Reactions: Sensitivity reactions are uncommon but have come up; let a veterinarian know right away if anything unusual develops after the injection. Storage Information Room Temperature: Store vials somewhere cool and dry, maintaining a temperature of 68°F to 77°F and keeping them away from heat and light. Inspect Before Use: Check the vial before every use and set it aside if the solution looks off in color or has any visible particles or sediment in it. Out of Reach: Keep this medication somewhere that children and untreated animals in the home cannot get to it. NOTE: For generic medications, the product image shown may not reflect the actual item received. Generic medications can vary in size, color, and shape between orders depending on the manufacturer. Additionally, your medication may arrive packaged in a HardyPaw Pharmacy vial. Shipping & Return We offer ground, express, and priority delivery; see our shipping policy for details. For return instructions or product concerns, please refer to our detailed refund policy. Prescription items are NON-RETURNABLE and NON-REFUNDABLE. Frequently Asked Questions Q1: Is flunixin meglumine injection FDA-approved for horses and cattle? Ans: Flunixin meglumine injection carries FDA approval in horses for musculoskeletal pain and visceral pain from colic. In cattle, it is FDA-approved for managing fever and inflammation tied to respiratory disease, mastitis, and endotoxemia, all under veterinary supervision. Q2: Why should flunixin meglumine never be given intramuscularly to horses? Ans: Giving this medication into the muscle in horses opens the door to accidental intra-arterial injection, which can trigger ataxia, incoordination, rapid breathing, and agitation. In cattle, intramuscular use has been linked to violative tissue residues at slaughter. The intravenous route under veterinary supervision is the only appropriate method for horses. Q3: How quickly does flunixin meglumine injection work in horses? Ans: The intravenous formulation acts faster than the oral paste, which is why it is the go-to option for acute situations like colic or endotoxic shock. Depending on what is driving the pain, the relief it provides can last anywhere from one hour to over 24 hours. Q4: What animals should not receive flunixin meglumine injection? Ans: Animals that are dehydrated, hypovolemic, or hypotensive should not receive this medication, nor should those with liver, kidney, or cardiovascular conditions without close veterinary oversight. It is also off limits for animals intended for human consumption, and extra care is needed in foals, pregnant mares, and older horses. Q5: Can flunixin meglumine injection be combined with other pain medications in horses? Ans: Combining this medication with other NSAIDs or corticosteroids is not safe and significantly raises the risk of gastrointestinal ulcers and organ toxicity. When combination treatment is needed, a veterinarian should keep a close eye on how the drugs are interacting and adjust the plan accordingly. Clinical Research https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=676272e8-e602-4db1-9d80-0bbdf8e568f8 https://pubmed.ncbi.nlm.nih.gov/23040013/
