Pure Encapsulations Folate 5,000 Plus Activated folate, vitamin B12, and B6 combination Folate 5,000 Plus provides 5,000 mcg of folate as methyltetrahydrofolate (5-MTHF), the universally metabolized and biologically active form of folate, combined with activated vitamin B12 and B6. Genetic variations affecting activation and metabolism of supplemental folic acid are common. Through bypassing several enzymatic activation steps catalyzed by DHFR (dihydrofolate reductase) and MTHFR (methylenetetrahydrofolate reductase), 5-MTHF is directly usable by the body and provides all of the benefits of folic acid regardless of functional or genetic variations in these enzymes. Activated B vitamins provide methyl groups to support healthy methylation, a key regulator of genetic expression and cellular function. Healthy methylation is vital for cellular health, hormone and neurotransmitter production, and energy metabolism. Key Benefits and Features: Ages 18 and up Cellular, neuronal, and positive mood support Provides the active form of folate, directly bioavailable without metabolic activation Supports cellular and neuronal health Promotes healthy neurotransmitter function and positive mood 5,000 mcg of activated folate per capsule Combination of activated B vitamins Made with high-quality, vegan ingredients backed by verifiable science Ingredients Serving Size: 1 Vegetarian Capsule Amount/Serving Vitamin B6 (as pyridoxal 5' phosphate (activated B6)) 25 mg Folate (as Metafolin, L-5-MTHF) 8,333 mcg DFE (5,000 L-5-MTHF) Vitamin B12 (as methylcobalamin) 1,000 mcg Other Ingredients: Hypoallergenic plant fiber (cellulose), vegetarian capsule (cellulose, water). Does Not Contain: Wheat, soy, dairy, egg, tree nuts, peanuts, gluten, artificial colors, artificial flavors, artificial sweeteners, coating, shellacs, GMOs, unnecessary binders, fillers, preservatives, magnesium stearate, trans fat, and hydrogenated oils. Gluten-Free, Non-GMO, Vegan, Vegetarian Suggested Use As a dietary supplement, take 1 capsule daily, with a meal or as directed by a health professional. Warning: Use only under medical supervision. If you are pregnant or lactating, have any health condition, or are taking any medication, consult your health professional before use. Storage: Store in a cool, dry place. More Info. At the molecular level, the main function of folate is to donate methyl groups in key biochemical reactions occurring in blood cells, neurons, the vasculature, and many other tissues. In addition, folate promotes the production of healthy DNA. Research suggests that B vitamins help maintain healthy nervous system function. In a randomized controlled study, a combination of methylfolate, Methylcobalamin, and pyridoxal-5-phosphate promoted healthy epidermal nerve fiber density and nerve comfort. Methyltetrahydrofolate and methylcobalamin may also support psychological health, including positive mood. Metafolin®, L-5-methyltetrahydrofolate (L-5- MTHF), and pyridoxal 5’ phosphate are synthetic Methylcobalamin is derived from corn dextrose fermentation Hypoallergenic plant fiber is derived from pine cellulose
