By Pure Encapsulations ctivated folate, vitamin B12 and B6 combination Folate 5,000 Plus provides 5,000 mcg of folate as 5-methyltetrahydrofolate (5-MTHF), the universally metabolized and biologically active form of folate, combined with activated vitamin B12 and B6. Optimal levels of these B vitamins have been associated with cellular, cardiovascular, neurological and emotional health. Activated B vitamins provide methyl groups to support healthy methylation, a key regulator of genetic expression and cellular function. Healthy methylation is vital for cellular health, hormone and neurotransmitter production, and energy metabolism. Research suggests that B vitamins help maintain a healthy nervous system function. In a randomized controlled study, a combination of methylfolate, methycobalamin, and pyridoxal-5-phosphate promoted healthy epidermal nerve fiber density and nerve comfort. These vitamins also enhance healthy endothelial function and play a vital role in the metabolism of homocysteine.*
