FRIO® INSULIN COOLING CASES provide a highly effective, yet low-cost solution to the problem of keeping insulin at a safe temperature without the need for ice packs or refrigeration. The FRIO® is the most simple and convenient medication cooling system available. The FRIO® Insulin Cooling Case is a reusable evaporative cooler whose cooling properties do not come from an icepack - or anything that needs refrigeration. Its cooling properties come from the evaporation of water. When activated, it keeps its low temperature for a minimum of two days, even in temperatures of 100 degrees Fahrenheit. With the FRIO®, the person dependent on medication that must remain cool is not dependent on ice packs in any way or at any time.. For a FRIO® to be activated, simply soak it in water for 5-10 minutes. It retains its cooling properties for a minimum of two full days. After that, re-soak your FRIO® in water and it is good for another two days - and so on, and so on.. - Keeps Insulin cool and safe - Insulating qualities help protect Insulin from cold - Activated by cold water only - No refrigeration or ice needed - Light and compact * Only for shipping in The US. Non-US orders will be replaced with Poucho Insulin Cooling Wallet of corresponding size in color Black. - Reusable FRÍO® Insulin Cooling Case - Duo wallet is ideal for carrying various combinations of pens, vials and cartridges as follows: A) 2 x insulin injection pens - either pre-filled disposable pens or refillable pens (not incl.) or B) One insulin pen plus 2 x 3ml cartridges or one insulin pen plus 3 x 1.5ml cartridges (not incl.) or C) 2 x 10ml vials of insulin and syringes (not incl.) Inner Wallet Dimensions: 83mm x 180mm (3.5" x 7"approx) COLOR GREEN DISCONTINUED - NO LONGER AVAILABLE - ALL OTHER COLORS AVAILABLE. Orders in Green will be replaced with color Black