Whether you are insulin dependent or have to carry another type of temperature-sensitive medication, the FRIO Cooling Case is your answer. The FRIO is a reusable evaporative cooler. Its cooling properties come from the evaporation of water, not an ice pack or anything that needs refrigeration. Once activated, by soaking the case in water for 5-10 minutes, it keeps medications within the safe range of 64.4-78.8°F (18-26°C) for a minimum of 45 hours, even in a constant environmental temperature of 100°F. For longer periods, simply re-soak in water and you’re good for another 45 hours! The FRIO offers better convenience than an ice pack and cooler with its size and design. *The FRIO is not, and is not intended to be, a refrigerator substitute. Keeps insulin cool and safe within its cool, safe range range of 64.4-78.8°F (18-26°C) Insulating qualities help protect insulin from cold Activated by water No refrigeration or ice needed Light and compact, and reusable Ideal for carrying various combinations of pens and vials, as follows: 4 x insulin pens (not incl.), 2 Trulicity (not incl.), 2 EpiPens (not incl.) or 6 x 10ml vials of insulin and syringes (not incl.) Inner Wallet Dimensions: 140 mm x 180 mm (5.5″ x 7″ approx)