FritzZyme® MONSTER 360 No Need for Refrigeration Two Year Shelf Life Freshwater Specific Formula Great for Use After Maintenance Easy Dosing Works in Every Type of System Can Be Used with All Other FritzZyme Products FritzZyme® MONSTER 460 No Need for Refrigeration Two Year Shelf Life Saltwater-Specific Formula Great for Use After Maintenance Easy Dosing Works in Every Type of System Can Be Used with All Other FritzZyme Products Directions & DosageInitial dose: Use 5 mL (1 tsp) per 25 US gallons (95 L). Maintenance dosing: Use 5 mL (1 tsp) per 50 US gallons (190 L) after regular maintenance, or at the interval of your choice. For a large livestock system or systems with heavy bioload, new system dosage may be safely increased up to 5x. For best results, add directly to aquarium in an area of high flow All chlorine and chloramines must be removed from water before adding FritzZyme® Monster 460 Maintain adequate water flow or aeration Discontinue use of skimmer and UV sterilizers for at least 48 hours after application No contraindications: can be used with all of our other products and meds Safe for use with all species, including aquatic plants and invertebrates Safe to add directly into a tank with livestock present Variations of odor and color between bottles is normal, a strong sulfur smell does not mean the bacteria are dead Overdosed? Heterotrophic bacteria are very safe even if overdosed. Observe for any distress, increase aeration and perform small water changes if necessary