BRAIN SLEEP SUPPLEMENT GABA

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When sleep quality is poor, the brain and body cannot fully rest, making it difficult to draw out one’s true performance.GABA is expected to help improve sleep quality, including deeper sleep and a clearer, more refreshed awakening. ISSUE Sleep quality affects daytime productivity Declining sleep quality has been reported in recent years to significantly impact work performance, leading to losses for businesses and organizations.It is also said that many industrial accidents are caused by sleep deprivation or sleep-related disorders. Sleep does not feel truly restful lately Waking up frequently during the night Difficulty waking up feeling refreshed in the morning In response Improved sleep quality and daytime performance can be changed by a supplement Focusing on the brain and the gut, which influence each other Activating the autonomic nervous system that connects the gut to the brainTo help transform sleep The gut, sometimes referred to as the “second brain,” has its own neural network and can function independently without direct commands from the brain.The brain and the gut constantly exchange information, influencing each other in a two-way manner.This relationship is known as the “brain–gut interaction.” For example, when stress is felt, stomach discomfort may occur.This happens because the brain transmits stress signals to the gut through the autonomic nervous system. Signals from the brain to the gut For example, stress can alter gut motility, leading to constipation or diarrhea. Signals from the gut to the brain For example, changes in the gut environment may cause feelings of anxiety or promote relaxation. Activating the autonomic nervous system that connects the gut to the brainTo help transform sleep The gut, sometimes referred to as the “second brain,” has its own neural network and can function independently without direct commands from the brain.The brain and the gut constantly exchange information, influencing each other in a two-way manner.This relationship is known as the “brain–gut interaction.” For example, when stress is felt, stomach discomfort may occur.This happens because the brain transmits stress signals to the gut through the autonomic nervous system. With just one capsule a dayA dual approach to sleep and the gut Food with function claims TECHNOLOGY 01GABA supports improved sleep quality and helps reduce stress 02Lactic acid bacteria approach from the gut 03Easy to take just one capsule per day 01GABA GABA supports improved sleep quality and helps reduce stress GABA is included at 100 mg as a functional ingredient that supports improvements in sleep quality—such as deeper sleep and a refreshed feeling upon waking—and helps reduce temporary mental stress and fatigue caused by work or study. Learn more about the evidence Changes observed over 7 days:Increased duration of deep sleep and improved mood upon waking. [Study method]Ten healthy adult men and women who reported concerns about sleep quality(ages 24–57; 6 men, 4 women) were divided into two groups.Capsules containing 100 mg of GABA or capsules without GABA were administered for 7 days, followed by a 7-day washout period.The groups were then crossed over, and each capsule was administered for an additional 7 days.[Source]Yamatsu A., et al. Food Science and Biotechnology, 2016, 25(2), 547–551.Partially modified. Changes observed over 7 days:Increased duration of deep sleep and improved mood upon waking. [Study method]Ten healthy adult men and women who reported concerns about sleep quality(ages 24–57; 6 men, 4 women) were divided into two groups.Capsules containing 100 mg of GABA or capsules without GABA were administered for 7 days, followed by a 7-day washout period.The groups were then crossed over, and each capsule was administered for an additional 7 days.[Source]Yamatsu A., et al. Food Science and Biotechnology, 2016, 25(2), 547–551.Partially modified. How GABA leads to “deep sleep” and a “clear, refreshed awakening” How GABA leads to “deep sleep” and a “clear, refreshed awakening” GABA acts on the autonomic nervous system, suppressing sympathetic nerve activity and promoting parasympathetic dominance, which supports a relaxed state and leads to deeper sleep.As a result, sleepiness upon waking is reduced, contributing to a clearer, more refreshed awakening. Supporting people living in a high-stress society Supporting people living in a high-stress society When fatigue or stress is felt, GABA is consumed in large amounts to help relieve it and can become insufficient.GABA supports the reduction of temporary mental stress and feelings of fatigue caused by work or study. Learn more about the evidence A reduction in stress within 30 minutes,with fatigue alleviated by 55% [Study design] A randomized, double-blind, placebo-controlled crossover study was conducted in 19 healthy adult men (mean age: 29 years).Participants in the intervention group consumed coffee containing 28 mg of GABA, while the placebo group consumed coffee without GABA.After intake, participants performed a 17-minute arithmetic task designed to induce stress and fatigue.Stress levels before and after the task were evaluated by measuring salivary chromogranin A (CgA).Subjective fatigue was assessed using a self-administered questionnaire based on the visual analog scale (VAS).[Source]Yamatsu A., et al. Yakuri to Chiryo (Pharmacology and Therapeutics), 2015, 43(4), 515–519.Partially modified. A reduction in stress within 30 minutes,with fatigue alleviated by 55% [Study design] A randomized, double-blind, placebo-controlled crossover study was conducted in 19 healthy adult men (mean age: 29 years).Participants in the intervention group consumed coffee containing 28 mg of GABA, while the placebo group consumed coffee without GABA.After intake, participants performed a 17-minute arithmetic task designed to induce stress and fatigue.Stress levels before and after the task were evaluated by measuring salivary chromogranin A (CgA).Subjective fatigue was assessed using a self-administered questionnaire based on the visual analog scale (VAS).[Source]Yamatsu A., et al. Yakuri to Chiryo (Pharmacology and Therapeutics), 2015, 43(4), 515–519.Partially modified. 02LACTIC ACID BACTERIA Lactic acid bacteria approach from the gut, helping support digestive balance. A plant-based lactic acid bacteria K-1, deeply familiar to the Japanese diet A plant-based lactic acid bacteria K-1, deeply familiar to the Japanese diet Derived from rice, a long-standing staple of the Japanese diet, this lactic acid bacteria is known for its natural compatibility.Unlike animal-based lactic acid bacteria cultivated in nutrient-rich milk, plant-based lactic acid bacteria have adapted to survive in harsher environments—low in nutrients, low in temperature, and high in acidity and salinity.Because of this resilience, they are believed to remain active and effective even within the digestive tract. Changes cut conditioning in 14 days Changes cut conditioning in 14 days [Participants]95 adults (ages 20–64) with a tendency toward constipation[Test food]A food containing 50 billion CFU/day of plant-based lactic acid bacteria K-1(L. casei 327), or a control food**The control food did not contain plant-based lactic acid bacteria K-1(L. casei 327) and was identical in appearance, taste, and aroma.[Source]Saito Y., et al. Biosci Microbiota Food Health, 2018, (3), 59–65.Figure created based on Table 3.*p < 0.05, statistically significant compared with the control. 03EASY WELLNESSROUTINE Easy to take—just one capsule a day, manufactured in a GMP-certified facility. Just one capsule a day, easy to keep upevery day. Just one capsule a day, easy to keep upevery day. A single capsule delivers GABA equivalent to approximately 30 cherry tomatoes, along with lactic acid bacteria comparable to about 50 servings of yogurt—making it easy to maintain as part of a daily routine.Packaged in a compact pouch, it’s also convenient to carry wherever you go. Manufactured at a GMP-certified facility in Toyama, Japan Manufactured at a GMP-certified facility in Toyama, Japan GMP certification refers to manufacturing standards established by the Ministry of Health, Labour and Welfare of Japan.These standards ensure appropriate manufacturing and quality control throughout the entire process, from raw material intake to production and shipment. 3 TYPES OF SUPPLEMENTS3 types of supplements to choose from For those concerned about cold hands and feet or swelling Sleep Stress Gut health + Warmth support ¥4,320 (tax included)30 capsules / 1 month supply Basic sleep care Sleep Stress Gut health ¥3,240 (tax included)30 capsules / 1 month supply For those concerned about body fat Sleep Stress Gut health + Diet support ¥4,320 (tax included)30 capsules / 1 month supply Supplement GABA Basic sleep care Sleep Stress Gut health Two ingredients, three functional benefits in a single capsuleFor sleep, stress, and gut balance Two ingredients, three functional benefits in a single capsuleFor sleep, stress, and gut balance GABA Improves sleep quality GABA Reduces stress and fatigue Lactic acid bacteria Helps regulate gut condition Notification of functional claims This product contains GABA and plant-derived lactic acid bacteria K-1 (L. casei 327).GABA has been reported to help improve sleep quality, including sleep depth and a refreshed feeling upon waking.It has also been reported to help reduce temporary mental stress and feelings of fatigue caused by work or study.Plant-derived lactic acid bacteria K-1 (L. casei 327) has been reported to help regulate gut condition and improve bowel movements.[Consumer Affairs Agency notification number: J462] Supplement GABA + Thermo For those concerned about cold hands and feet or swelling Sleep Stress Gut health Warming support Three ingredients, four functional benefits in a single capsuleSupporting sleep, stress, gut health, and cold sensitivity & swelling Three ingredients, four functional benefits in a single capsuleSupporting sleep, stress, gut health, and cold sensitivity & swelling GABA Improves sleep quality GABA Reduces stress and fatigue Lactic acid bacteria Helps regulate gut condition Long pepper–derived piperine compounds Helps reduce cold sensitivity in the hands and feet*¹ and leg swelling *² *¹ Decrease in peripheral (hands and feet) skin temperature due to cold *² Temporary, non-pathological leg swelling in healthy women Notification of functional claims This product contains GABA, plant-derived lactic acid bacteria K-1 (L. casei 327), and long pepper–derived piperine compounds.GABA has been reported to help improve sleep quality (depth of sleep and refreshed awakening). It has also been reported to help reduce temporary psychological stress and fatigue caused by work or study.Plant-derived lactic acid bacteria K-1 (L. casei 327) has been reported to help regulate bowel movements and improve intestinal conditions.Long pepper–derived piperine compounds have been reported to help normalize reduced peripheral blood flow caused by cold exposure and to alleviate decreases in peripheral (hands and feet) skin surface temperature due to cold. They have also been reported to help reduce temporary, non-pathological leg swelling in healthy women.[Consumer Affairs Agency notification number: J1140] CIRCULATIONSUPPORT CIRCULATIONSUPPORTSupport for cold sensitivity and swelling Cold sensitivity occurs when small blood vessels constrict, leading to reduced blood flow to the extremities.Long pepper–derived piperine compounds, a functional ingredient, have been reported to help improve blood circulation and reduce decreases in body surface temperature caused by cold.By supporting healthy circulation, they also help alleviate swelling. Piperine compounds from long pepper, a spice and traditional botanical with a long history Piperine compounds from long pepper, a spice and traditional botanical with a long history Long pepper is a spice native to South Asia and has been traditionally used for centuries in Ayurveda in India and in traditional Chinese medicine.Piperine compounds found in this historically valued botanical have been reported to help support healthy circulation from within the body. Long pepper–derived piperine compounds 120µg Reduces cold sensitivity in the hands and feet*¹, as well as leg swelling *² *¹ Reduction in decreases in skin surface temperature of the extremities (hands and feet) caused by cold *² Temporary, non-pathological swelling of the legs in healthy women Mechanism supporting improved circulation and cold sensitivity relief Mechanism supporting improved circulation and cold sensitivity relief Piperine compounds derived from long pepper act on capillaries, helping to relax vascular constriction and promote blood circulation, thereby improving blood flow to the extremities. As a result, cold sensitivity in the hands and feet is reduced and overall body temperature balance is supported. Learn more about the evidence Reduced hand coldness in 10 minutes [Study design] A study was conducted in 30 healthy Japanese women.Participants were given either a capsule containing 120 µg of long pepper–derived piperines or a placebo capsule without piperines.Ten minutes after ingestion, subjects immersed their hands in 18°C cold water for one minute (cold stress load). Blood flow and skin temperature were then measured for 10 minutes.After a one-week washout period, the groups were crossed over and the same protocol was repeated.[Source] Yoshino S., et al. Yakuri to Chiryo, 2018; 46(2): 219–225. Adapted from original data. Improvement in swelling within 6 hours [Study design] A study was conducted in 36 healthy adult women.Participants were given either a capsule containing 120 μg of long pepper–derived piperines or a placebo capsule. After water intake and prolonged sitting, the edema index—measured as the extracellular water ratio (ECW/TBW)—was evaluated.[Source] Fujimoto T., et al. Yakuri to Chiryo, 2020, 48(3), 401–407. (Partially modified) Why people who feel cold struggle to fall asleep Under normal conditions, heat is released from the skin through the capillaries, lowering core body temperature and helping the body transition into sleep.However, in people who are prone to feeling cold, poor circulation in the hands and feet can disrupt this mechanism, making it harder to fall asleep. Supplement GABA + Diet For those concerned about body fat Sleep Stress Gut health Diet Three ingredients. Four functional benefits.Supports sleep, stress, gut health, and body fat. Three ingredients. Four functional benefits.Supports sleep, stress, gut health, and body fat. GABA Improves sleep quality GABA Reduces stress and fatigue Lactic acid bacteria Helps regulate gut condition Ellagic acid Helps improve body weight, body fat, triglycerides, and BMI*¹ *For individuals who are overweight, helps reduce body weight, body fat, blood triglycerides, visceral fat, waist circumference, and high BMI. Notification of functional claims This product contains GABA, plant-derived lactic acid bacteria K-1 (L. casei 327), and ellagic acid.GABA has been reported to help improve sleep quality (depth of sleep and feeling refreshed upon waking). It has also been reported to help reduce temporary psychological stress and fatigue caused by work or study.Plant-derived lactic acid bacteria K-1 (L. casei 327) has been reported to help regulate intestinal conditions and improve bowel movements.Ellagic acid has been reported to support reductions in body weight, body fat, blood triglycerides, visceral fat, and waist circumference, and to help improve elevated BMI.[Consumer Affairs Agency notification number: J11141] DIET SUPPORT DIET SUPPORTSupports healthy weight management Weight gain can occur due to a decline in basal metabolism and the accumulation of body fat.Ellagic acid, a functional ingredient, works on fat metabolism to help reduce body weight and body fat.By supporting metabolic function, it also contributes to the maintenance of a healthy body composition. Three out of four people who struggle with snoring or sleep apnea are reported to have a BMI of 25 or higher Three out of four people who struggle with snoring or sleep apnea are reported to have a BMI of 25 or higher Multiple studies indicate that a large proportion of individuals with sleep concerns have a BMI of 25 or above.[Source] Esmaeili N., et al. eClinicalMedicine. 2025;83:103221. Ellagic acid extracted from pomegranate Ellagic acid extracted from pomegranate Used for over 5,000 years by those who value health and beauty, pomegranate contains ellagic acid, a naturally derived polyphenol.As it cannot be produced within the body, it must be obtained from external sources and is believed to support overall wellness. Ellagic acid 3mg Improves body weight, body fat, triglycerides, and BMI*¹ *For individuals with overweight tendencies: supports reductions in body weight, body fat, blood triglycerides, visceral fat, waist circumference, and elevated BMI values. How ellagic acid works on“inhibiting fat formation” and “regulating sugar metabolism” How ellagic acid works on“inhibiting fat formation” and “regulating sugar metabolism” Ellagic acid suppresses the formation and enlargement of fat cells and helps inhibit the uptake of dietary sugars into adipocytes, thereby blocking fat accumulation from multiple pathways.As a result, it supports reductions in body fat and triglycerides and contributes to the maintenance of a healthy body composition. Reductions in body weight, body fat, triglycerides, and waist circumference, along with improvements in elevated BMI, were observed over 12 weeks. Reductions in body weight, body fat, triglycerides, and waist circumference, along with improvements in elevated BMI, were observed over 12 weeks. [Study design] Thirty-two healthy adults (aged 20–64) with a BMI of 25 to Show more