GentleSpore combines three fully sequenced and registered spore-based probiotics to support a healthy microbiome. Each strain was specifically chosen for its mechanisms of action, backed by supporting research. Key Features Prebiotic-free, for sensitive patients Vegan, Dairy, Gluten & GMO-Free 11 billion CFU per dose No refrigeration required Spore-forming strains have several advantages over their live strain counterparts. Most notably, their ability to form a protective spore. This spore allows them to withstand much harsher environments such as those present in the stomach, allowing them to reach the intestines where their benefits can be fully realized. This also means they do not require refrigeration. Double-blind, randomized, placebo-controlled trials have established the safety of SBO’s for humans, and efficacy has been demonstrated in dozens of peer-reviewed published studies.