GIT2 (D391) Polyclonal Antibody Sizes: 50μl, 100μl Catalogue Numbers: BS2056-50, BS2056-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: Heterotrimeric G protein-mediated signal transduction is a dynamically regμlated process with the intensity of signal decreasing over time despite the continued presence of the agonist. G protein-coupled receptor kinases(GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade. GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicμlar trafficking. GIT1 overexpression resμlts in reduced internalization and resensitization of β2-adrenergic receptor, thus reducing β2-adrenergic receptor signaling. Category: Primary Antibody Reactivity: Human, Mouse, Rat Host: Rabbit Applications: IHC, IF Alternate Names: ARF GTPase-activating protein GIT2, ARF GAP GIT2, Cool-interacting tyrosine-phosphorylated protein 2, CAT-2, CAT2, G protein-coupled receptor kinase-interactor 2, GRK-interacting protein 2, KIAA0148, GIT2 Clonality: Polyclonal Conjugate: Unconjugated Modification: Unmodification Immunogen: Synthetic peptide, corresponding to amino acids 360-410 of Human GIT2. Dilution: IHC: 1:50~1:200 IF: 1:50~1:200 Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). Specificity: GIT2 (D391) polyclonal antibody detects endogenous levels of GIT2 protein. Molecular Weight: ~ 84 kDa Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. SwissProt: Q14161 Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Research Use Only
