Gladback™ is a purified and standardized fraction of Poria cocos for mature and/or menopause skins. It is a multi-functional active ingredient which increases skin thickness, radiance and microcirculation, and it also reduces the appearance of wrinkles typical of aging. Poria cocos is a well-known fungus in Asian traditional medicine where it is used as a purifying, antioxidant and softening agent. In GladbackTM, the part used is the sclerocia (mycelium), which is rich in polysacchrides (pachyman) and triterpenes. Target Dermal Structures of GladbackTM Hyaluronic acid: essential glycosaminoglycan of the dermal and epidermal extracellular matrix, which acts directly on tissue cohesion and repair. CD44: trans-membrane glycoprotein which acts as the main receptor of hyaluronic acid and maintains its homeostasis. The interaction between the hyaluronic acid and this receptor facilitates cellular differentiation and strengthens tissue union. During aging and menopause the expression of the CD44 receptor and hyaluronic acid diminishes, leading to a reduced skin thickness, firmness and cell renewal. Gladback™ increases the expression of this receptor, improving the hyaluronic acid binding in the epidermis and dermis. Collagen IV: maintains the skin mechanical stability as it is a key element of the dermal-epidermal junction. Age diminishes collagen and menopause accentuates even more this loss.Gladback™ boosts the expression of collagen IV and strengthens skin stability. SPRR: family of small proteins rich in prolin, located in the dense envelope of the corneocytes (epidermis). Due to aging and menopause these proteins become over expressed, and this causes important skin imbalances. Gladback™ reduces the expression of SPRR and improves the appearance of mature skin. Gladback™ rolls back the effects of aging in skin thickness, microcirculation, radiance and firmness. The result is a younger and more radiant skin. Cosmetic Applications Facial and corporal care for mature skins Anti-aging global lines Make up with treatment INCI: Water (and) Glycerin (and) Poria Cocos Polysaccharide Disclaimer Statements contained herein have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional skin care provider. California Prop 65 Statement: The following statement is made in order to comply with the California Safe Drinking Water and Toxic Enforcement Act of 1986. This product is not known to the State of California to cause cancer, birth defects or other reproductive harm. SDS & Tech Data To request technical documentation, please contact Lotioncrafter at [email protected] Formulation Guide Incorporation: Gladback™ should be added to the water phase or after the emulsion has formed at a temperature below 40°C (104°F).Recommended Usage Rate: 3-6%, safe up to 100%Appearance: Pale brown to brown transparent liquid, with turbiditySolubility: Water SolublepH as supplied: 4.5 - 5.5Glycerin Source: Brassica campestris - PALM FREERaw Material Preserved with: Gluconolactone, Calcium Gluconate, Potassium Sorbate, Sodium BenzoateCountry of Origin: SpainStorage: Clean, cool room temperature storage, out of direct sunlight. Try out these formulations using this ingredient: Antiaging Facial Moisturizer for Mature Skin
