Product Details Glutathione is a water-soluble peptide made up of three amino acids: glutamine, glycine, and cysteine. It is an antioxidant that is present in all cells. Glutathione is a unique antioxidant, as it is produced in the liver. Most antioxidants have to be consumed through diet or supplements. Several factors can reduce glutathione levels, including diet, stress, aging, and environmental toxins. What is Glutathione Reduced? Glutathione is present in the body in two forms. Reduced glutathione (GSH) hasn’t exerted any antioxidant effects, whereas oxidized glutathione (GSSG) has expended its antioxidant properties. Reduced glutathione usually makes up the bulk of glutathione in the body, accounting for 98%. A change in the ratio of reduced glutathione to oxidized glutathione can indicate a negative shift in cellular health. Potential Glutathione Benefits Glutathione is a powerful antioxidant. It scavenges free radicals and reduces oxidative stress. Oxidative stress can damage cells, cause strand breaks in DNA, and interrupt cell signaling. One of the most prominent free radicals is hydrogen peroxide. Glutathione scavenges hydrogen peroxide radicals and reduces them into water and oxygen. Glutathione may also support liver health. An antioxidant deficiency can damage liver cells. Glutathione may be able to support liver health by replenishing antioxidant levels. Glutathione may support digestive health as well. Rises in oxidative stress cause inflammation in the intestines. Glutathione is the main antioxidant present in gastrointestinal cells. As an antioxidant, glutathione may help reduce inflammation and oxidative stress in the digestive tract. Glutathione for Skin One of the most common uses of glutathione for skin is as a lightening agent. Glutathione may lighten skin by interfering with melanin synthesis. Several studies examined the effects of glutathione on skin lightening and found that glutathione lowered participants’ melanin index scores. Glutathione and Citrulline Malate Glutathione synergizes with citrulline malate and may improve exercise performance. Exercise performance has direct ties to nitric oxide (NO). NO is a vasodilator, which helps deliver nutrients to muscle cells faster. Citrulline malate increases NO production and decreases muscle soreness. However, blood levels of NO break down quickly. Taking glutathione with citrulline malate may help synthesize NO to improve exercise performance. Glutamine and Alpha Lipoic Acid Maintaining a balance of reduced and oxidized glutathione is critical for overall health. However, changes in cellular health can interfere with this ratio. Glutathione can’t cross between cells. Instead, L-cystine, the oxidized form of l-cysteine, transfers between cells. These l-cysteine molecules are critical for synthesizing glutathione. Alpha lipoic acid (ALA) can reduce l-cystine into two l-cysteine molecules to facilitate a faster increase in reduced glutathione. Potential Side Effects of Glutathione Glutathione is well-tolerated by most individuals. Some potential side effects include abdominal cramping and bloating. Consult with your doctor before starting a new supplement. References https://pubmed.ncbi.nlm.nih.gov/14988435/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431659/ https://pubmed.ncbi.nlm.nih.gov/20700719/ https://www.ncbi.nlm.nih.gov/pubmed/18616466 https://www.ncbi.nlm.nih.gov/pubmed/11351128 https://www.ncbi.nlm.nih.gov/pubmed/8888724 https://www.ncbi.nlm.nih.gov/pubmed/10470601 https://www.ncbi.nlm.nih.gov/pubmed/10830784 https://www.ncbi.nlm.nih.gov/pubmed/7569285 https://www.ncbi.nlm.nih.gov/pubmed/21908948 https://www.ncbi.nlm.nih.gov/pubmed/20386132 http://www.ncbi.nlm.nih.gov/pubmed/26097441 https://www.ncbi.nlm.nih.gov/pubmed/1784629 https://www.ncbi.nlm.nih.gov/pubmed/9288403 https://www.ncbi.nlm.nih.gov/pubmed/1784629 https://www.ncbi.nlm.nih.gov/pubmed/27088927 https://www.ncbi.nlm.nih.gov/pubmed/25378941 https://www.ncbi.nlm.nih.gov/pubmed/28490897 Tested by Accredited 3rd Party Labs PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here. *NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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