Provides 5-MTHF (5-methyltetrahydrofolate) — the biologically active, metabolically ready form of folate that does not require enzymatic conversion by the body. Many individuals carry a common genetic variant (MTHFR polymorphism) that reduces their ability to convert folic acid or standard folate into the active 5-MTHF form. This Life Extension formula delivers a high-potency 5000 mcg dose of 5-MTHF directly, bypassing this conversion step entirely. Folate (vitamin B9) is essential for DNA synthesis, cardiovascular health (via homocysteine metabolism), neurological function, and is particularly critical during pregnancy for foetal neural tube development. Life Extension has been formulating science-backed supplements for over 40 years. 30 vegetarian tablets. Supplement Facts Per serving (1 tablet) %NRV* Folate (as [6S]-5-methyltetrahydrofolic acid / 5-MTHF) 5000 mcg 2500% *NRV = Nutrient Reference Value. NRV for Folate = 200 mcg. Directions for use: Take 1 tablet daily with or without food, or as recommended by a healthcare professional. Do not exceed the recommended dose without medical supervision. Ingredients: 5-methyltetrahydrofolate (5-MTHF) (as [6S]-5-methyltetrahydrofolic acid glucosamine salt) 5000 mcg. Other Ingredients: Microcrystalline cellulose, dicalcium phosphate, stearic acid, croscarmellose sodium, silicon dioxide, coating (hydroxypropyl methylcellulose, glycerin). FAQs What is the difference between folic acid and 5-MTHF?Folic acid is a synthetic form of folate that must be converted by the body into 5-MTHF (the active form) before it can be used. A significant proportion of the population — estimated at 40–60% — has reduced activity of the MTHFR enzyme needed for this conversion. 5-MTHF bypasses this step entirely, providing the active form directly. Who might benefit from this high-potency formula?Those with MTHFR gene variants, individuals with elevated homocysteine levels, women planning a pregnancy or who are pregnant, and anyone who may have difficulty converting folic acid may benefit from supplementing with 5-MTHF directly. Always consult a healthcare professional. Is this product suitable for vegans?Yes — Life Extension High Potency Optimized Folate is free from animal-derived ingredients. Can I take this alongside a B-complex supplement?Yes — 5-MTHF works synergistically with other B vitamins, particularly B12 (as methylcobalamin) and B6, for homocysteine support. It is commonly taken as part of a broader B-vitamin protocol. Is this the same as the folate found in food?Dietary folate is converted to 5-MTHF in the gut wall during absorption. This supplement provides 5-MTHF directly, mirroring the form that circulates in the bloodstream.
