Pure Encapsulations Hist Reset Modulates Mast Cell and Immune Mediator Activation Histamine is a substance found in many foods, such as meat, spinach, avocados, nuts, tomatoes, and chocolate, or released as part of the local immune response by immune cells, primarily mast cells, upon exposure to an immune trigger. Some individuals have difficulty breaking down histamine. This formula is designed to modulate mast cell and immune mediator activation, support healthy histamine metabolism, and promote respiratory and tissue health. Quercetin, luteolin, and rutin are flavonoids known to exhibit antioxidant and immune-modulating activity. Key Benefits and Features: Ages 18 and up Individuals who experience symptoms of histamine intolerance, such as general fatigue or discomfort, occasional GI upset, skin sensitivity, or flushing Individuals with a polymorphism in the AOC1gene Multi-faceted support for nasal and respiratory health Promotes healthy mast cell stabilization Supports healthy histamine metabolism 100 mg luteolin per serving Includes flavonoids quercetin, luteolin, and rutin for antioxidant and immune support Ingredients Serving Size: 2 Vegetarian Capsules Amount/Serving Vitamin C (as ascorbic acid) 250 mg Riboflavin 5 mg Niacin (as niacinamide) 20 mg Molybdenum (as molybdenum glycinate) 100 mcg N-Acetyl-L-Cysteine 100 mg Quercetin 300 mg Bromelain (from pineapple stem) (2,400 GDU/gram) 200 mg Luteolin 100 mg Rutin 100 mg Other Ingredients: Vegetarian capsule (cellulose and water). Does Not Contain: Wheat, soy, dairy, eggs, artificial colors, artificial sweeteners, coatings, shellacs, GMOs, tree nuts, peanuts, sesame, unnecessary binders, fillers, preservatives, magnesium stearate, gluten, trans fat, and hydrogenated oils. Gluten Free, Non-GMO, Vegan, Vegetarian, Hypoallergenic Suggested Use As a dietary supplement, take 2 capsules daily, between meals, or as directed by a health professional. Warning: Not to be taken by pregnant or lactating women. If you have any health conditions or are taking any medication, consult your health professional before use. Storage: Store in a cool, dry place. More Info. In vitro studies involving mast cells suggest that these compounds help to stabilize mast cells and modulate the release of immune mediators, including histamine, leukotrienes, and prostaglandins. The mechanism of action is believed to be in part due to modulating extracellular signal-regulated kinases, including PKC. Animal studies suggest that these flavonoids can moderate IgE antibody-mediated responses in skin. Bromelain (from pineapple) acts as a protease, promoting healthy levels of kinins to support tissue comfort. Research suggests that bromelain also supports healthy T cell function and cytokine production. Riboflavin, niacinamide, and molybdenum are included as cofactors for aldehyde dehydrogenase, a key enzyme in the breakdown of histamine. Preliminary research suggests that supplementation with vitamin C modulates bronchial responsiveness to histamine in sensitive subjects. Optimal vitamin C serum levels have been associated with lower blood histamine levels. NAC promotes immune and lung defense through mucolytic and antioxidant actions. It acts as a free radical scavenger by supporting glutathione production. Due to its sulfur content, NAC is able to disrupt disulfide bonds within mucus, thinning and easing its expulsion, along with the trapped particles, from the lungs.
