Omne Diem Histamine Digest supplies Diamine Oxidase (DAO), the enzyme that neutralizes histamine in the digestive tract. Taking Omne Diem Histamine Digest prior to consuming high histamine foods and beverages defends against digestive histamine sensitivity and the occurrence of accompanying reactions. Omne Diem Histamine Digest supplies Diamine Oxidase (DAO), the enzyme that neutralizes histamine in the digestive tract. Taking Omne Diem Histamine Digest prior to consuming high histamine foods and beverages defends against digestive histamine sensitivity and the occurrence of accompanying reactions. Natural Our DAO is a natural enzyme-rich protein extract from porcine kidney that is delivered to the small intestine. Convenient DAO promotes histamine degradation within 20 min after intake. Safe DAO is not absorbed into the body and no adverse events have been recorded with DAO supplementation. What is Histamine? Histamine is a biogenic amine present in our bodies and in our food supply. Biogenic amines are found in everything from dairy products and meats to fruits, vegetables and grains. Processes that result in the microbial alteration of foods — such as aging (meat), fermentation (wine, spirits, cheese), and package processing (prepared packed foods) — can increase the levels of histamine and other biogenic amines in foods and beverages. Omne Diem™ Histamine Digest supplies Diamine Oxidase, the enzyme that neutralizes dietary histamine in the digestive tract. Taking Omne Diem™ Histamine Digest prior to consuming high histamine foods and beverages defends against digestive histamine sensitivity to help reduce the occurrence of histamine intolerance. Allergy or Intolerance? While the symptoms of Histamine Intolerance (HIT) may mimic allergic reactions, HIT is not a classical food allergy. Rather, research suggests that HIT is mediated by a deficiency in levels and/or activity of the Diamine Oxidase enzyme. Allergy – An immune system response to a specific allergenic substance. Symptoms can appear quickly with very little exposure. Intolerance – An "allergy-like" reaction that does not involve an immunological response. Reactions can take time to appear and increase upon level of exposure. Symptoms of Histamine Intolerance While the symptoms of Histamine Intolerance (HIT) may mimic allergic reactions, HIT is not a classical food allergy. Rather, research suggests that HIT is mediated by a deficiency in levels and/or activity of the Diamine Oxidase enzyme. Reactions are variable, seem unrelated and are widespread. Common reactions include: Vasodilation (flushing/reddening) Hypotension/Tachycardia Stuffy, Runny Nose/Sneezing Swelling or Red, Watery Eyes Headache or Migraine Diarrhea, Cramps, Bloating Feelings of Anxiety Urticaria (hives) Prevalence Indication Percentage of Western Population Lactose Intolerance 10-30% Fructose Malabsorption 33% Food Allergy 3-5% Histamine Intolerance 2-5% Celiac Disease 0.5% Fructose Intolerance