Histamine Digest supplies Diamine Oxidase (DAO), the enzyme that neutralizes histamine in the digestive tract.* Taking Histamine Digest prior to consuming high histamine foods and beverages defends against digestive histamine sensitivity and the occurrence of accompanying reactions.* Our DAO is a natural enzyme-rich protein extract from porcine kidney that is delivered to the small intestine. DAO is not absorbed into the body and no adverse events have been recorded with DAO supplementation. How Histamine Digest Works Diamine Oxidase (DAO) is responsible for the degradation of biogenic amines ingested with food (exogenous histamine). DAO is active in the ilium and jejunum of the small intestine. It is also found concentrated in the kidney, thymus and placenta. When histamine levels in the digestive tract become excessive, DAO breaks down the excess. When there is a deficiency of available DAO or DAO activity is blocked, reactions can occur. Omne Diem Histamine Digest supplies natural, active supplemental DAO to help neutralize excess histamine.*
