Formula Overview HistDAO provides 20,000 HDU of diamine oxidase activity per tablet, sourced from a concentrated porcine kidney extract. The proprietary gastro-resistant coating is designed to release the DAO in the small intestine where ingested histamine is processed. A note from Evey Histamine has a job in the body, but ingested histamine, the kind that comes in with certain foods, needs to be broken down efficiently in the small intestine before it reaches circulation. Diamine oxidase, or DAO, is the protein that does that work at the gut wall. HistDAO delivers a concentrated source of DAO, sourced from porcine kidney, in a gastro-resistant mini-tablet that holds together through the stomach so the active material is released where it belongs. What sets this formula apart is the dose and the delivery. Each tablet provides 20,000 HDU of DAO activity, the amount used in the published research, and the gastro-resistant coating is what allows that activity to reach the small intestine intact. This is a quiet nutrition support, the kind that closes a gap rather than makes a statement. Some people are simply more sensitive than others to histamine in foods. When that sensitivity flares, the obvious move is to look at the plate, but matching upstream gut function with what is on the plate is part of the fuller picture, and a more honest one than chasing every reaction downstream. I generally suggest one tablet shortly before a meal that is heavier in histamine-bearing foods. Form: Tablet, 60 count Disclosure: Evey Andersen, FNP-C, MSN, APNP, CISSN, is the owner of Green Medicine of Wisconsin and recommends this product based on clinical experience. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.