Genestra HMF™ Intensive (shelf-stable) Shelf-Stable Probiotic HMF™ Intensive provides a combination of human strain probiotics clinically demonstrated to support gastrointestinal health and comfort. Clinical trials have found that daily supplementation with HMF™ Intensive's probiotic formula helps support a healthy microflora composition in children, adolescents, and adults. Although the microflora composition in the gut is relatively steady, it can be altered by diet, stress, age, and medication use. In a randomized, placebo-controlled trial involving 155 adults, daily intake of a probiotic supplement providing 25 billion CFU (containing two strains each of Lactobacillus acidophilus and Bifidobacterium) for 21 days significantly and positively affected the intestinal microbiota. Additionally, a clinical trial reported that daily supplementation with this probiotic formula for eight weeks significantly improved several measures of intestinal comfort (abdominal comfort, bloating, satisfaction with bowel habits, and quality of life). This convenient shelf-stable format has guaranteed potency through expiration and may improve patient compliance. Key Benefits and Features: Provides 25 billion CFU per capsule Supports gastrointestinal health and comfort Balances microflora composition No refrigeration necessary Potency guaranteed through expiration Ingredients Serving Size: 1 Capsule Amount/Serving Probiotic Consortium 25 billion CFU Lactobacillus acidophilus (CUL-60 & CUL-21) Bifidobacterium animalis subsp. lactis (CUL-34) Bifidobacterium bifidum (CUL-20) Other Ingredients: Microcrystalline cellulose and hypromellose. Non-GMO, Gluten Free, Soy Free, Dairy Free, No FOS, Vegan Suggested Use Adults, Adolescents and Children (6 years and older): Take 1 capsule daily with a meal, or as recommended by your health professional. Warning: If you have an immunocompromised condition, do not use. If you are pregnant or lactating, have any health condition, or are taking any medication, consult your health professional before use. If symptoms of digestive upset occur, stop use and consult your health professional. Keep out of the reach of children. This product was sealed for your protection. Do not use if box or contents are open or damaged. Storage: Store in a cool, dry place. More Info. HMF™ Intensive is formulated using Genestra Brands®' proprietary Lactobacillus and Bifidobacterium probiotic consortium - microorganisms that have been used in a wide body of clinical research. Studies demonstrate that these human strain probiotics effectively maximize intestinal colonization to promote the growth of beneficial bacteria and support gastrointestinal comfort. In addition, these strains are selected based on their high quality, viability and strong epithelial adherence. They also demonstrated naturally high tolerance to stomach and bile acid in preclinical research. The human intestinal tract contains more than 400 bacterial species. This microflora composition can be altered by a number of factors, including diet, occasional stress, certain medications, aging and travel. When the microflora balance is affected in the intestines, common gastrointestinal complaints can occur, including mild bloating and gas. Probiotics are defined by the World Health Organization as "live microorganisms which when administered in adequate amounts confer a health benefit on the host". Probiotics have been found to support gastrointestinal health and contribute to a healthy microflora composition. Studies have shown that they mediate microbial colonization and support the growth of beneficial bacteria in the intestines. Probiotics accomplish this by mediating intestinal pH and strengthening the epithelial barrier. They mediate the integrity of tight junctions and increase mucin release, which in turn regulates permeability and reduces microbial adherence to cells. In one double-blind, placebo-controlled trial, HMF™ Probiotics were found to modulate the intestinal microflora composition. Participants were divided into two groups, receiving either a probiotic or placebo supplement for 21 days. Fecal samples were collected at baseline (day one) and on days seven and 35 to determine the average bacterial composition. Each probiotic capsule was taken once daily and contained 2.5X10 CFU from a combination of two strains of Lactobacillus acidophilus (CUL-60 and CUL-21), Bifidobacterium bifidum (CUL-20) and Bifidobacterium animalis subsp. lactis (CUL-34). HMF probiotic supplementation helped to support the growth of beneficial strains and maintain a healthy microflora balance. In an eight-week long, double-blind, randomized, placebo-controlled study involving 52 adults, supplementation with HMF™ Intensive's probiotic formula significantly reduced mild intestinal discomfort. Participants were randomized to either the placebo or probiotic capsule group (25 billion CFU from CUL-60, CUL-21, CUL-34 and CUL-20) and consumed one capsule daily for eight weeks. Participants scored their intestinal discomfort (including bloating, satisfaction with bowel habits and quality of life) at baseline and every two weeks during the supplementation significantly improved intestinal discomfort scores, including a 22% decrease in days with intestinal discomfort, 32% improvement in satisfaction with bowel habits and 30% improvement in quality of life scores. These improvements were also significantly greater when compared to placebo values.
