Specification Full name HSPA5 rabbit polyclonal antibody Alternative names 50 μl/100 μl Reactivity rabbit polyclonal Applications WB, IHC Host Rabbit Clone type rabbit polyclonal Target Background The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. Swissprot No P11021 Gene Accession NP_005338 WB Predicted band size 72 kDa WB Positive control WB Recommended dilution 500-2000 IHC predicted cell location Predicted cell location: Cytoplasm IHC positive control Positive control: Human liver cancer IHC Recommed dilution Recommended dilution: 50-200 Storage -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol WB PIC Description P113651-WB-1-P IHC PIC Description Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue or HSPA5 antigen-treated (Neutralization experiment) using P113651(HSPA5 Antibody) at dilution 1/50
