Human CSK Active Catalog number: B2014043 Lot number: Batch Dependent Expiration Date: Batch dependent Amount: 10 μg Molecular Weight or Concentration: 52 kDa Supplied as: Solution Applications: molecular tool for various biochemical applications Storage: −20°C Keywords: CSK, active, untagged human Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um. References Roskoski R Jr. Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors Pharmacol Res. 2015 Apr;94:9-25. Courtney AH, Shvets AA, Lu W, Griffante G, Mollenauer M, Horkova V, Lo WL, Yu S, Stepanek O, Chakraborty AK, Weiss A. CD45 functions as a signaling gatekeeper in T cells Sci Signal. 2019 Oct 22;12(604):eaaw8151. Song L, Liu Z, Hu HH, Yang Y, Li TY, Lin ZZ, Ye J, Chen J, Huang X, Liu DT, Zhou J, Shi Y, Zhao H, Xie C, Chen L, Song E, Lin SY, Lin SC. Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy Nat Commun. 2020 Nov 17;11(1):5842. Cui N, Liu T, Guo Y, Dou J, Yang Q, Zhang H, Chen R, Wang Y, Zhao X, Yu J, Huang J. SUMOylation of Csk Negatively Modulates its Tumor Suppressor Function Neoplasia. 2019 Jul;21(7):676-688. Martinon F, Chen X, Lee AH, Glimcher LH. TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages Nat Immunol. 2010 May;11(5):411-8. Dias RVR, Ferreira CTA, Jennings PA, Whitford PC, Oliveira LC. Csk C Helix: A Computational Analysis of an Essential Region for Conformational Transitions J Phys Chem B. 2022 Dec 22;126(50):10587-10596. Chong YP, Mulhern TD, Cheng HC. C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)–endogenous negative regulators of Src-family protein kinases Growth Factors. 2005 Sep;23(3):233-44. Howell BW, Cooper JA. Csk suppression of Src involves movement of Csk to sites of Src activity Mol Cell Biol. 1994 Aug;14(8):5402-11. Lu W, Skrzypczynska KM, Weiss A. Acute Csk inhibition hinders B cell activation by constraining the PI3 kinase pathway Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2108957118.
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