Human DNMT3B/DNMT3L Complex (recombinant) Catalog number: B2016789 Lot number: Batch Dependent Expiration Date: Batch dependent Amount: 10 µg Molecular Weight or Concentration: 59 kDa (DNMT3B) and 27 kDa (DNMT3L) Supplied as: Solution Applications: a molecular tool for various biochemical applications Storage: -80°C Keywords: DNA (Cytosine-5)-Methyltransferase 3B, DNA (Cytosine-5)-Methyltransferase 3-Like, DNA Methyltransferase HsaIIIB, DNA MTase HsaIIIB, M.HsaIIIB Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um. References Gao L, Guo Y, Biswal M, Lu J, Yin J, Fang J, Chen X, Shao Z, Huang M, Wang Y, Wang GG, Song J. Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations Nat Commun. 2022 Jul 22;13(1):4249. Cho CC, Lin CJ, Huang HH, Yang WZ, Fei CY, Lin HY, Lee MS, Yuan HS. Mechanistic Insights into Harmine-Mediated Inhibition of Human DNA Methyltransferases and Prostate Cancer Cell Growth ACS Chem Biol. 2023 Jun 16;18(6):1335-1350. Jiang Y, Schneck JL, Grimes M, Taylor AN, Hou W, Thrall SH, Sweitzer SM. Methyltransferases prefer monomer over core-trimmed nucleosomes as in vitro substrates Anal Biochem. 2011 Aug 1;415(1):84-6. Zhu X, Xue C, Kang X, Jia X, Wang L, Younis MH, Liu D, Huo N, Han Y, Chen Z, Fu J, Zhou C, Yao X, Du Y, Cai W, Kang L, Lyu Z. DNMT3B-mediated FAM111B methylation promotes papillary thyroid tumor glycolysis, growth and metastasis Int J Biol Sci. 2022 Jul 4;18(11):4372-4387. Zhang H, Ying H, Wang X. Methyltransferase DNMT3B in leukemia Leuk Lymphoma. 2020 Feb;61(2):263-273. Li G, Luo R, Zhang W, He S, Wang B, Liang H, Song Y, Ke W, Shi Y, Feng X, Zhao K, Wu X, Zhang Y, Wang K, Yang C. m6A hypomethylation of DNMT3B regulated by ALKBH5 promotes intervertebral disc degeneration via E4F1 deficiency Clin Transl Med. 2022 Mar;12(3):e765. Gagliardi M, Strazzullo M, Matarazzo MR. DNMT3B Functions: Novel Insights From Human Disease Front Cell Dev Biol. 2018 Oct 22;6:140. Man X, Li Q, Wang B, Zhang H, Zhang S, Li Z. DNMT3A and DNMT3B in Breast Tumorigenesis and Potential Therapy Front Cell Dev Biol. 2022 May 10;10:916725. Okano M, Bell DW, Haber DA, Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development Cell. 1999 Oct 29;99(3):247-57.
