Human Factor Xa Catalog number: B2013656 Lot number: Batch Dependent Expiration Date: Batch dependent Amount: 0.8 mg Molecular Weight or Concentration: 46 kDa Supplied as: Solution Applications: molecular tool for various biochemical applications Storage: -20°C Keywords: Human Factor Xa Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um. References Siegal DM, Curnutte JT, Connolly SJ, Lu G, Conley PB, Wiens BL, Mathur VS, Castillo J, Bronson MD, Leeds JM, Mar FA, Gold A, Crowther MA. Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity N Engl J Med. 2015 Dec 17;373(25):2413-24. Newall F. Anti-factor Xa (anti-Xa) assay Methods Mol Biol. 2013;992:265-72. Nederpelt CJ, Naar L, Krijnen P, le Cessie S, Kaafarani HMA, Huisman MV, Velmahos GC, Schipper IB. Andexanet Alfa or Prothrombin Complex Concentrate for Factor Xa Inhibitor Reversal in Acute Major Bleeding: A Systematic Review and Meta-Analysis Crit Care Med. 2021 Oct 1;49(10):e1025-e1036. Escolar G, Diaz-Ricart M, Arellano-Rodrigo E. Andexanet alfa: a recombinant mimetic of human factor Xa for the reversal of anticoagulant therapies Drugs Today (Barc). 2017 May;53(5):271-282. Becker RC. Factor Xa inhibitors: critical considerations for clinical development and testing J Thromb Thrombolysis. 2021 Aug;52(2):397-402. Thalji NK, Camire RM. Rendering factor Xa zymogen-like as a therapeutic strategy to treat bleeding Curr Opin Hematol. 2017 Sep;24(5):453-459. Connors JM. Antidote for Factor Xa Anticoagulants N Engl J Med. 2015 Dec 17;373(25):2471-2. Sible AM, Nawarskas JJ. Andexanet Alfa for Reversing Factor Xa Inhibition Cardiol Rev. 2019 Mar/Apr;27(2):108-111. Monkovic DD, Tracy PB. Activation of human factor V by factor Xa and thrombin Biochemistry. 1990 Feb 6;29(5):1118-28.
