Human PAD4

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Human PAD4 Peptidylarginine deiminase 4 (PAD4) is an enzyme that catalyzes the conversion of arginine residues in proteins to citrulline, a process known as citrullination or deimi nation. This post-translational modification can alter protein structure, charge, and function, influencing processes such as gene regulation, chromatin remodeling, and immune responses. PAD4 has been linked to autoimmune diseases like rheumatoid arthritis and might be involved in neutrophil extracellular trap (NET) formation. Show more