Human Prothrombin Complex Catalog number: B2012314 Lot number: Batch Dependent Expiration Date: Batch dependent Amount: 50 IU Molecular Weight or Concentration: NA Supplied as: Lyophilized Applications: molecular tool for various biochemical applications Storage: -20C Keywords: PCC Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um. References Nederpelt CJ, Naar L, Krijnen P, le Cessie S, Kaafarani HMA, Huisman MV, Velmahos GC, Schipper IB. Andexanet Alfa or Prothrombin Complex Concentrate for Factor Xa Inhibitor Reversal in Acute Major Bleeding: A Systematic Review and Meta-Analysis Crit Care Med. 2021 Oct 1;49(10):e1025-e1036. N Engl J Med. 1965 Sep 23;273(13):715-6. doi: 10.1056/NEJM196509232731311. Human prothrombin complex N Engl J Med Schwebach AA, Waybright RA, Johnson TJ. Fixed-Dose Four-Factor Prothrombin Complex Concentrate for Vitamin K Antagonist Reversal: Does One Dose Fit All? Pharmacotherapy. 2019 May;39(5):599-608. Stevens VM, Trujillo TC, Kiser TH, MacLaren R, Reynolds PM, Mueller SW. Retrospective Comparison of Andexanet Alfa and 4-Factor Prothrombin Complex for Reversal of Factor Xa-Inhibitor Related Bleeding Clin Appl Thromb Hemost. 2021 Jan-Dec;27:10760296211039020. Bertolaccini ML. Antibodies to prothrombin Lupus. 2012 Jun;21(7):729-31. Kamihara Y, Kikuchi S, Wada A, Murakami J, Sugie N, Niimi H, Nakashima A, Sato T. [Successful preoperative replacement of prothrombin with prothrombin complex concentrate for Prothrombin Himi] Rinsho Ketsueki. 2021;62(9):1412-1414. Green D. Pathophysiology of Antiphospholipid Syndrome Thromb Haemost. 2022 Jul;122(7):1085-1095. DeWitt RT, Feinstein DI. Prothrombin complex concentrate Arch Intern Med. 1977 Sep;137(9):1211-3. Eltringham-Smith LJ, Yu R, Qadri SM, Wang Y, Bhakta V, Pryzdial EL, Crosby JR, Ni H, Sheffield WP. Prothrombin, alone or in complex concentrates or plasma, reduces bleeding in a mouse model of blood exchange-induced coagulopathy Thromb Haemost. 1991 Dec 2;66(6):629-32.
