Human Serum Proteins for Interference Testing Catalog # K2010001E Lot # Batch Dependent Expiration Batch Dependent Volume 1 mL Appearance Yellow orange Origin Human Matrix Filtered human serum albumins Storage –20°C or lower; aliquot to avoid freeze-thaw Other Names Human Serum Albumins, Albumin, Total Serum Proteins This filtered human serum protein solution is formulated for interference testing in biochemical and clinical assay workflows. Supplied in 1 mL aliquots and derived from human serum albumins, the yellow-orange solution enables researchers to simulate matrix effects and assess assay robustness under physiologically relevant protein concentrations. It is ideal for validating immunoassays, spectrophotometric platforms, and protein-binding studies. Human serum proteins are known to influence assay performance through nonspecific binding, background signal elevation, and competitive interactions. This reagent allows for controlled spiking into specimens to evaluate analytical sensitivity, specificity, and cross-reactivity. The solution is filtered for clarity and consistency, and should be aliquoted upon receipt to avoid repeated freeze-thaw cycles. Applications include method validation, QC benchmarking, and interference panel construction. Key benefits: Filtered human serum protein solution for interference testing Derived from albumin-rich human serum matrix Supports immunoassay, spectrophotometry, and protein-binding platforms Stable at –20°C; aliquot recommended Ideal for assay validation and matrix effect simulation Indication for Use:This product is for Research Use Only (RUO). This product is not for administration to humans or animals. This product is not for human or veterinary diagnostic or therapeutic use. All Interference Products Brochure Download PDF References: Schiettecatte J et al. Interferences in Immunoassays. Adv Immunoassay Tech. 2012. Miller JJ, Levinson SS. Interferences In Immunoassays. Immunoassay. 1996;165–190. Ward G. Immunoassay interference investigations. Pathology. 2013;45. Park JY, Kricka LJ. Immunoassay interference. Immunoassay Handbook. 2013;403–416. EP07: Interference Testing in Clinical Chemistry. CLSI. 2020. Gilles A et al. Targeting the 80S ribosome in cancer. Cells. 2020;9(3):E629. Coussens NP et al. Assay interference in proximity assays. Assay Guidance Manual. 2020. Wang L et al. Fluorescent probes for nitric oxide. Org Biomol Chem. 2020;18(8):1522–1549. Kawasaki H et al. Drosophila GBA mutant phenotypes. Gene. 2017;614:49–55. Hull B. HAMA interference with TSH assay. J S C Med Assoc. 2012;108(1):12–13. Degn SE et al. Rat kappa light-chain interference. J Immunol Methods. 2011;372(1–2):204–8.
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