humanN Berberine delivers pharmaceutical-grade Berberine HCl at a clinically meaningful dose — a polyphenol alkaloid with one of the most robust clinical evidence bases of any natural compound for blood sugar regulation, insulin sensitivity, and cholesterol management. Formulated by the team behind the Nobel Prize-backed Nitric Oxide science of SuperBeets. 30 capsules.Berberine activates AMPK (AMP-Activated Protein Kinase) — the same metabolic enzyme activated by exercise and metformin — improving insulin receptor sensitivity and glucose transporter (GLUT4) expression. Multiple meta-analyses of randomized controlled trials confirm Berberine significantly reduces fasting blood glucose, HbA1c, total cholesterol, LDL cholesterol, and triglycerides while increasing HDL. The effect size for Berberine on blood sugar and lipids is comparable to pharmaceutical interventions in many studies. humanN (HumanN) is a cardiovascular health supplement company built on Nobel Prize-winning Nitric Oxide science from the University of Texas Health Science Center, trusted by cardiologists, medical professionals, and collegiate athletic programs nationwide. Available at Beauty Riche with same-day shipping.