カテゴリ: 論文誌(論文単位)グループ名: 【C】電子・情報・システム部門発行日: 2024/05/01タイトル(英語): Ultrasound-Responsive Liposome-Encapsulated Gel Patches Drug Delivery Model著者名: Kano Kajie (Tokyo Institute of Technology), Shoichiro Kanno (Tokyo Institute of Technology), Zugui Peng (Tokyo Institute of Technology), Kenta Shimba (The University of Tokyo), Takashi Shibata (The University of Toyama), Yoshitaka Miyamoto (National Cente著者名(英語): Kano Kajie (Tokyo Institute of Technology), Shoichiro Kanno (Tokyo Institute of Technology), Zugui Peng (Tokyo Institute of Technology), Kenta Shimba (The University of Tokyo), Takashi Shibata (The University of Toyama), Yoshitaka Miyamoto (National Center for Child Health and Development), Tohru Yagi (Tokyo Institute of Technology)キーワード: transdermal drug delivery system (TDDS)，liposome，ultrasound (US)，controlled release，hydrogel要約(英語): Transdermal drug delivery system is a technique that delivers drugs via transdermal absorption, and we have studied ultrasound-responsive liposome-encapsulated gel patches for this system. The liposomes contained the drug models to prevent the leakage through the gel pores and to provide sustained release. The drug models could also be released by breaking the liposomes by ultrasound irradiation. In this study, we investigate the optimal parameters of gel patches for this model. Nanosized liposomes containing fluorescent compounds as drug models are embedded in agarose gels of different concentrations, and the gel concentration that most efficiently traps the liposomes are selected. Furthermore, we investigate the ultrasound intensity that best promotes drug model release by irradiating ultrasound at different intensities and observing the fluorescent intensity of the buffer solution outside the patch before and after irradiation with a spectrophotometer.本誌: 電気学会論文誌C（電子・情報・システム部門誌） Vol.144 No.5 （2024） 特集：医用・生体工学関連技術本誌掲載ページ: 465-466 p原稿種別: 研究開発レター／英語電子版へのリンク: https://www.jstage.jst.go.jp/article/ieejeiss/144/5/144_465/_article/-char/ja/
