Product Details What Is Inositol Hexanicotinate? Inositol hexanicotinate, also known as inositol nicotinate, is a nutritional supplement taken as a flush-free niacin (vitamin B3) analog. It is inositol esterified with niacin. Niacin is essential for converting food into useable energy in the body. It also acts as an antioxidant and may support healthy blood fat levels. Inositol, sometimes referred to as vitamin B8, is a water-soluble, fatty lipid needed for the formation and maintenance of healthy cell membranes. The hydrolysis of 1g inositol hexanicotinate breaks down the compound into 0.91g nicotinic acid and 0.22g inositol. What is the Niacin Flush? Niacin is an essential vitamin, but it often produces a "niacin flush." It stimulates prostaglandin D2 production, a lipid that causes blood vessels to dilate. The sudden surge in these lipids also boosts blood flow, thus triggering a flush response. Flushing characteristics include tingling and itching sensations, skin redness or warmth, sweating, shortness of breath, increased heart rate, chills, dizziness, and even fainting. Inositol Hexanicotinate: Flush-Free Niacin Inositol hexanicotinate provides the benefits of niacin without its characteristic flush. The body metabolizes inositol hexanicotinate slower than niacin, requiring 6-10 hours to reach peak serum levels compared to 0.5-1 hour. Nicotinamide is another flush-free niacin compound. Potential Niacin Benefits Niacin is a vital, water-soluble form of vitamin B3, also called niacin, nicotinic acid, nicotinamide, and niacinamide. Niacin is one of the most stable water-soluble vitamins, as it resists the effects of heat, light, air, acid, and alkali. The small intestines absorb niacin readily. Small amounts may be kept in the liver, but the body excretes from of the excess through urine. The body can’t produce niacin and relies on dietary sources. Niacin for Energy and Antioxidant Activity Vitamin B3 helps to catalyze or speed up the chemical reactions responsible for generating energy in the body, breaking down dietary fats, creating certain hormones, boosting good cholesterol, processing genetic material (DNA), and the growth and maturation of the cells in the body. It’s a precursor to nicotinamide adenine dinucleotide (NAD), a compound essential for several REDOX reactions. One of these reactions transfers electrons to provide energy at the cellular level. It also energizes antioxidant enzymes and provides the NAD molecules that protect against oxidative stress and repair free radical damage. Niacin and Blood Fats Niacin exerts several effects on various blood fats. It’s able to increase high-density lipoprotein (HDL) cholesterol (good cholesterol) while decreasing low-density lipoprotein (LDL) cholesterol (bad cholesterol) and triglycerides. It can boost HDL by more than 30% while lowering triglycerides by 25%. More HDL cholesterol also contributes to lower LDL cholesterol, as it helps remove bad cholesterol from the bloodstream. Potential Side Effects of Inositol Hexanicotinate Most individuals can take inositol hexanicotinate without experiencing adverse effects. Some individuals may experience gastrointestinal side effects, such as stomach upset, headache, nausea, burping, and hiccups. It can cause liver damage if taken in excessive amounts. Those taking prescription drugs to treat high cholesterol or elevated blood lipid levels should consult the prescribing physician before taking this product. Check with a health care provider before using inositol hexanicotinate if you have a heart condition, diabetes, kidney problems, or liver disease. Do not take inositol hexanicotinate while pregnant or breastfeeding. Purity and Concentration of Inositol Hexanicotinate PureBulk’s inositol hexanicotinate powder contains no fillers, additives, or anti-caking agents. How Should I Store It? PureBulk packages inositol hexanicotinate powder in a resealable bag. Store it in a cool, dry area protected from light. Reseal after each use. References & Further Research https://efsa.onlinelibrary.wiley.com/doi/pdf/10.2903/j.efsa.2009.949 https://pubchem.ncbi.nlm.nih.gov/compound/Inositol-niacinate https://www.ncbi.nlm.nih.gov/pubmed/164246 https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/ https://www.ncbi.nlm.nih.gov/pubmed/26828517 https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/niacin/art-20046208 https://lpi.oregonstate.edu/mic/vitamins/niacin https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional https://www.sciencedirect.com/science/article/pii/B9780123918826000078 https://www.britannica.com/science/niacin https://pubmed.ncbi.nlm.nih.gov/28616955/ https://pubmed.ncbi.nlm.nih.gov/27793642/ https://pubmed.ncbi.nlm.nih.gov/33404619/ https://www.ncbi.nlm.nih.gov/pubmed/16322797 https://bio.libretexts.org/Bookshelves/Microbiology/Book%3A_Microbiology_(Bruslind)/12%3A_Energetics_and_Redox_Reactions https://www.ncbi.nlm.nih.gov/pubmed/18165311 https://www.ncbi.nlm.nih.gov/pubmed/7641178 https://www.ncbi.nlm.nih.gov/pubmed/20725615 https://pubmed.ncbi.nlm.nih.gov/25306426/ https://www.ncbi.nlm.nih.gov/pubmed/7657446 https://www.ncbi.nlm.nih.gov/pubmed/12100180 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779993/ https://pubmed.ncbi.nlm.nih.gov/22037771/ Tested by Accredited 3rd Party Labs PureBulk's supplements are tested by accredited third party labs in the USA to ensure their identity, purity and potency. To receive a copy of these test results or any other PureBulk supplement please fill out the COA request form found here. *NOTE: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
